Evidence map›Paper›PMID 28460824›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017

Regional susceptibility to dose-dependent white matter damage after brain radiotherapy.

Michael Connor, Roshan Karunamuni, Carrie McDonald, Tyler Seibert, Nathan White, Vitali Moiseenko, Hauke Bartsch, Nikdokht Farid, Joshua Kuperman, Anitha Krishnan and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04343157 (UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases), which is not on this map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04343157 phase2recruitingnot on this mapstarted 2019, after this paper: background citation

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases: Avoidance of Eloquent White Matter and Hippocampal Regions

TypeinterventionalSponsorJona Hattangadi-GluthRan2019 to 2028Enrolled60ConditionsBrain Metastases, Adult, Neurocognitive Function, CancerArmsCognitive Sparing Brain Stereotactic Radiosurgery (SRS)
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael ConnorDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States.
Roshan KarunamuniDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Carrie McDonaldDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Department of Psychiatry, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Tyler SeibertDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Nathan WhiteDepartment of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Vitali MoiseenkoDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States.
Hauke BartschDepartment of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Nikdokht FaridDepartment of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Joshua KupermanDepartment of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Anitha KrishnanDepartment of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Anders DaleDepartment of Radiology, University of California San Diego, La Jolla, California, United States; Department of Psychiatry, University of California San Diego, La Jolla, California, United States; Department of Neurosciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
Jona A Hattangadi-GluthDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States. Electronic address: jhattangadi@ucsd.edu.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
San Diego Clinical and Translational Research InstituteKL2TR000099 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$1.1M
San Diego Clinical and Translational Research InstituteKL2RR031978 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$615k
HSRD VA TPR 15-229NCATS NIH HHS KL2 TR000099NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR001442NCI NIH HHS P30 CA023100NCRR NIH HHS KL2 RR031978NINDS NIH HHS R01 NS065838
6 · The paper itself

Abstract

background and purposeRegional differences in sensitivity to white matter damage after brain radiotherapy (RT) are not well-described. We characterized the spatial heterogeneity of dose-response across white matter tracts using diffusion tensor imaging (DTI). MATERIALS AND

methodsForty-nine patients with primary brain tumors underwent MRI with DTI before and 9-12months after partial-brain RT. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were generated. Atlas-based white matter tracts were identified. A secondary analysis using skeletonized tracts was also performed. Linear mixed-model analysis of the relationship between mean and max dose and percent change in DTI metrics was performed.

resultsTracts with the strongest correlation of FA change with mean dose were the fornix (-0.46 percent/Gy), cingulum bundle (-0.44 percent/Gy), and body of corpus callosum (-0.23 percent/Gy), p<.001. These tracts also showed dose-sensitive changes in MD and RD. In the skeletonized analysis, the fornix and cingulum bundle remained highly dose-sensitive. Maximum and mean dose were similarly predictive of DTI change.

conclusionsThe corpus callosum, cingulum bundle, and fornix show the most prominent dose-dependent changes following RT. Future studies examining correlation with cognitive functioning and potential avoidance of critical white matter regions are warranted.

Indexed as

AdultBrain NeoplasmsDiffusion Tensor ImagingDose-Response Relationship, RadiationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWhite MatterDiffusion tensor imagingDose-dependentRadiationRadiotherapyWhite matter

Identifiers

PMID28460824
PMCPMC5518466

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.