ArticleInfectious diseases of poverty2017
Multi-locus variable-number tandem repeat analysis of Chinese Brucella strains isolated from 1953 to 2013.
Article in Infectious diseases of poverty, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Global Comprehensive Literature Review and Meta-Analysis of Brucella spp. in Swine Based on Publications From 2000 to 2020.Frontiers in veterinary science · 2021Pooled it
- Epidemiological surveillance of BVDV, Pasteurella multocida, and Brucella spp. infections in cattle from Guizhou, China using a newly established triplex TaqMan qPCR assay.Veterinary research communications · 2026Article
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- Analysis of the Brucella melitensis epidemic in Xinjiang: genotyping, polymorphism, antibiotic resistance and tracing.Annals of clinical microbiology and antimicrobials · 2024Article
- Molecular epidemiological characteristics of osteoarthritis-associated Brucella melitensis in China: evidence from whole-genome sequencing-based analysis.Annals of clinical microbiology and antimicrobials · 2024Article
- Molecular epidemiological characteristics ofFrontiers in microbiology · 2023Article
- Molecular characteristics of Brucella melitensis isolates from humans in Qinghai Province, China.Infectious diseases of poverty · 2021Article
- Evaluation and Differential Diagnosis of a Genetic Marked Brucella Vaccine A19ΔvirB12 for Cattle.Frontiers in immunology · 2021Article
- Analysis of Clinical Manifestations of Acute and Chronic Brucellosis in Patients Admitted to a Public General Hospital in Northern China.International journal of general medicine · 2021Article
- Whole-genome sequencing of roughEmerging microbes & infections · 2020Article
- Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin.PLoS neglected tropical diseases · 2020Article
- Emerging Brucellosis Outbreaks Associated with Unpasteurized Milk in China.China CDC weekly · 2020Article
- Molecular Characteristics ofFrontiers in microbiology · 2020Article
- Article
- Investigation of the molecular characteristics of Brucella isolates from Guangxi Province, China.BMC microbiology · 2019Article
- A case report on mother-to-child transmission of Brucella in human, China.BMC infectious diseases · 2019Article
- Enzootic situation and molecular epidemiology of Brucella in livestock from 2011 to 2015 in Qingyang, China.Emerging microbes & infections · 2018Article
- Genetic Characterization of AnimalBioMed research international · 2018Article
- Multiple Locus Variable-Number Tandem-Repeat and Single-Nucleotide Polymorphism-BasedFrontiers in veterinary science · 2017Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBrucellosis was a common human and livestock disease caused by Brucella strains, the category B priority pathogens by the US Center for Disease Control (CDC). Identified as a priority disease in human and livestock populations, the increasing incidence in recent years in China needs urgent control measures for this disease but the molecular background important for monitoring the epidemiology of Brucella strains at the national level is still lacking.
methodsA total of 600 Brucella isolates collected during 60 years (from 1953 to 2013) in China were genotyped by multiple locus variable-number tandem repeat analysis (MLVA) and the variation degree of MLVA11 loci was calculated by the Hunter Gaston Diversity Index (HGDI) values. The charts and map were processed by Excel 2013, and cluster analysis and epidemiological distribution was performed using BioNumerics (version 5.1).
resultsThe 600 representative Brucella isolates fell into 104 genotypes with 58 singleton genotypes by the MLVA11 assay, including B. melitensis biovars 2 and 3 (five main genotypes), B. abortus biovars 1 and 3 (two main genotypes), B. suis biovars 1 and 3 (three main genotypes), and B. canis (two main genotypes) respectively. While most B. suis biovar 1 and biovar 3 were respectively found in northern provinces and southern provinces, B. melitensis and B. abortus strains were dominant in China. Canine Brucellosis was only found in animals without any human cases reported. Eight Brucellosis epidemic peaks emerged during the 60 years between 1953 and 2013: 1955 - 1959, 1962 - 1969, 1971 - 1975, 1977 - 1983, 1985 - 1989, 1992 - 1997, 2000 - 2008 and 2010 - 2013 in China.
conclusionsBrucellosis has its unique molecular epidemiological patterns with specific spatial and temporal distribution according to MLVA.
trial registrationIDOP-D-16-00101.
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