Evidence map›Paper›PMID 28460534›Full record

Trial reportBiological research for nursing2017

A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors.

Richard R Reich, Cecile A Lengacher, Thomas W Klein, Cathy Newton, Steve Shivers, Sophia Ramesar, Carissa B Alinat, Carly Paterson, Alice Le, Jong Y Park and 5 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biological research for nursing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Effects of a Single Session of Mindfulness and Compassion on Skin Temperature in Breast Cancer Survivors.International journal of environmental research and public health · 2024
    Article
  7. Review
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  11. Article
  12. Article
  13. Can Yogic Breathing Techniques LikeFrontiers in psychology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Richard R Reich1 Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Cecile A Lengacher2 College of Nursing, University of South Florida, Tampa, FL, USA.
Thomas W Klein3 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Cathy Newton3 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Steve Shivers4 Breast Health Clinical and Research Integrated Strategic Program, University of South Florida, Tampa, FL, USA.
Sophia Ramesar2 College of Nursing, University of South Florida, Tampa, FL, USA.
Carissa B Alinat2 College of Nursing, University of South Florida, Tampa, FL, USA.
Carly Paterson5 National Cancer Institute, Bethesda, MD, USA.
Alice Le2 College of Nursing, University of South Florida, Tampa, FL, USA.
Jong Y Park1 Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Versie Johnson-Mallard6 College of Nursing, University of Florida, Gainesville, FL, USA.
Maya Elias2 College of Nursing, University of South Florida, Tampa, FL, USA.
Manolete Moscoso2 College of Nursing, University of South Florida, Tampa, FL, USA.
Matthew Goodman7 Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Kevin E Kip8 Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
University of South Florida · USMoffitt Cancer Center · USNational Cancer Institute · USUniversity of Florida · USUniversity of Virginia · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
MBSR Symptom Cluster Trial for Breast Cancer SurvivorsR01CA131080 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2009 to 2013
$2.7M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA131080
6 · The paper itself

Abstract

purposeThe purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS).

methodA total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Plasma cytokines (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor [TNF] α, transforming growth factor [TGF] β1, soluble tumor necrosis factor receptor [sTNFR] 1) were assayed. Linear mixed models were used to assess cytokine levels across three time points (baseline and 6 and 12 weeks) by group (MBSR[BC] vs. UC).

resultsOf the six measured cytokines, three were nondetectable at rates greater than 50% (IL-10, IL-1β, TGF-β1) and, because of overall low prevalence, were not analyzed further. For the remaining cytokines (TNFα, IL-6, sTNFR1), results showed that TNFα and IL-6 increased during the follow-up period (between 6 and 12 weeks) rather than during the MBSR(BC) training period (between baseline and 6 weeks), while sTNFR1 levels did not change significantly across the 12-week period.

conclusionsStudy results suggest that MBSR(BC) affects cytokine levels in BCS, mainly with increases in TNFα and IL-6. The data further suggest that B-cell modulation may be a part of immune recovery during breast cancer management and that increases in TNFα and IL-6 may be markers for MBSR(BC)-related recovery.

Indexed as

MindfulnessAdultBiomarkersBreast NeoplasmsCancer SurvivorsCytokinesFemaleHumansInflammationMiddle AgedStress, PsychologicalBiomarkersCytokinesbiomarkersbreast cancercytokinesMBSR(BC)Mindfulness-Based Stress Reduction

Identifiers

PMID28460534
PMCPMC5942506
OpenAlexW2610354156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.