ArticleJournal of neurogastroenterology and motility2017
Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study.
Article in Journal of neurogastroenterology and motility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Alterations in short-chain fatty acids and serotonin in irritable bowel syndrome: a systematic review and meta-analysis.BMC gastroenterology · 2021Pooled it
- Neuropeptide Y Boosts Intestinal Mucosal Immunity of Tilapia Infected withAnimals : an open access journal from MDPI · 2025Article
- Digestive Manifestations of Post-COVID-19: A Focus on Therapeutic Strategies.Pathogens (Basel, Switzerland) · 2025Review
- Gut neuropeptide involvement in Parkinson's disease.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis.Frontiers in pharmacology · 2025Review
- Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis.Psychology research and behavior management · 2025Article
- Gut-directed therapy in Parkinson's disease.Frontiers in pharmacology · 2024Review
- Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study.Clinical and experimental gastroenterology · 2024Article
- Effectiveness of Group Emotional Schema Therapy on Psychological Distress, Severity and Frequency of Symptoms in Women with Irritable Bowel Syndrome.Advanced biomedical research · 2024Article
- Review
- Glucocorticoid receptor-mediatediScience · 2023Article
- Upregulation of spinal ASIC1 by miR-485 mediates enterodynia in adult offspring rats with prenatal maternal stress.CNS neuroscience & therapeutics · 2021Article
- Morphopathological changes in obsessive-compulsive disorder.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Article
- Neuropeptides in gut-brain axis and their influence on host immunity and stress.Computational and structural biotechnology journal · 2020Review
- Potential neuro-immune therapeutic targets in irritable bowel syndrome.Therapeutic advances in gastroenterology · 2020Review
- Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study.Journal of neurogastroenterology and motility · 2019Article
- Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2018Review
- Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?Gastroenterology research and practice · 2017Article
- Treating irritable bowel syndrome through an interdisciplinary approach.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsIrritable bowel syndrome (IBS) is a multifactorial disorder, involving dysregulation of brain-gut axis. Our aim was to evaluate the neuroendocrine activity in IBS.
methodsThirty IBS and 30 healthy volunteers were enrolled. Psychological symptoms were evaluated by questionnaires. Urinary 5-hydroxyindoleacetic acid, plasma serotonin (5-hydroxytryptamine, 5-HT), endothelin, and neuropeptide Y (NPY), and plasma and urinary cortisol levels were evaluated. Fourteen IBS subjects underwent microneurography to obtain multiunit recordings of efferent postganglionic muscle sympathetic nerve activity (MSNA).
resultsPrevalent psychological symptoms in IBS were maladjustment (60%), trait (40%) and state (17%) anxiety, obsessive compulsive-disorders (23%), and depressive symptoms (23%). IBS showed increased NPY (31.9 [43.7] vs 14.8 [18.1] pmol/L,
conclusionHigher concentrations of endothelin, NPY, and 5-HT were found to be associated with some psychological disorders in IBS patients together with an altered cardiovascular autonomic reactivity to acute stressors compared to healthy volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.