ArticleIranian biomedical journal2017
E6-Specific Detection and Typing of Human Papillomaviruses in Oral Cavity Specimens from Iranian Patients
Article in Iranian biomedical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Prevalence of oral HPV in healthy and lesion-bearing populations in Iran: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Prognostic Impact of HPV-PCR Positivity on Clinicopathological Parameters and Survival Outcomes in Oral Cavity Squamous Cell Carcinoma: A Cross-Sectional Study in Eastern India.Indian journal of surgical oncology · 2025Article
- Detection of Viruses with Oncogenic and Oncomodulatory Potential in Head and Neck Tumors-External Auricle.Biomedicines · 2025Article
- Molecular Prevalence of Human Papillomavirus Types 16 and 18 in Oral Squamous Cell Carcinoma using Real-time PCR.Archives of Razi Institute · 2024Article
- Human Papillomavirus and Risk of Head and Neck Squamous Cell Carcinoma in Iran.Microbiology spectrum · 2022Article
- Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders.Frontiers in genetics · 2019Review
- The prevalence and genotyping of human papillomavirus in patients with oral tumors in health centers and clinics of Mazandaran in Iran.Virusdisease · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Detection and quantification of human Papillomavirus (HPV) genome in oral carcinoma play an important role in diagnosis, as well as implications for progression of disease. Methods: We evaluated tissues from 50 esopharyngeal cancers collected from different regions of Iran for HPV E6 using the two type-specific primers sets. E6 gene of HPV genotypes was amplified by specific primers. The sensitivity of PCR assay was analyzed and determined using HPV-DNA-containing plasmids. Real-time PCR was utilized to determine the prevalence and HPV viral load in patients with oral cavity squamous cell carcinoma. Results: Eighteen (36%) specimens were positive for HPV. Among the 18 positive specimens, 10 showed HPV-18 (55.55%), and 8 specimens were positive for HPV-11 (44.44%). Of the 18 infected specimens, 6 (33.32%) and 12 (66.65%) were identified as high-titer and low-titer viral load, respectively. Conclusion: The PCR-based assay, developed in the current study, could be used for HPV detection, quantification, and genotyping in epidemiological and clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.