Evidence map›Paper›PMID 28460246›Full record

Trial reportAddictive behaviors2017

Integrated, exposure-based treatment for PTSD and comorbid substance use disorders: Predictors of treatment dropout.

Derek D Szafranski, Alexandra Snead, Nicholas P Allan, Daniel F Gros, Therese Killeen, Julianne Flanagan, Irene Pericot-Valverde, Sudie E Back

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Addictive behaviors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01338506 (Integrated Treatment of Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Post-traumatic Stress Disorder and Substance Use Disorders), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01338506 nacompletednot on this map

Integrated Treatment of Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Post-traumatic Stress Disorder and Substance Use Disorders

TypeinterventionalSponsorMedical University of South CarolinaRan2011 to 2016Enrolled81ConditionsPosttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug DependenceArmsConcurrent Treatment with Prolonged Exposure (COPE)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Substance Use Disorder Treatment Outcomes: Methodological Overview of Metrics and Criteria.International journal of methods in psychiatric research · 2025
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Discontinuation of mental health treatment among Canadian military personnel.Journal of military, veteran and family health · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Derek D SzafranskiRalph H. Johnson Veterans Affairs Medical Center, Charleston, SC, United States; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States. Electronic address: Derek.Szafranski@va.gov.
Alexandra SneadDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Nicholas P AllanRalph H. Johnson Veterans Affairs Medical Center, Charleston, SC, United States; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Daniel F GrosRalph H. Johnson Veterans Affairs Medical Center, Charleston, SC, United States; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Therese KilleenDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Julianne FlanaganDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Irene Pericot-ValverdeDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Sudie E BackRalph H. Johnson Veterans Affairs Medical Center, Charleston, SC, United States; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.

Funding

Drug Abuse Research Training (DART) ProgramR25DA020537 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, Sudie E Back · 2006 to 2026
$6.3M
Integrated Treatment of OEF/OIF Veterans with PTSD and Substance Use DisordersR01DA030143 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BACK, SUDIE E · 2010 to 2014
$1.6M
Integrating Neurobiology and Neuroimaging into Research on Addiction and PTSDK02DA039229 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BACK, SUDIE E · 2015 to 2019
$779k
Effects of Oxytocin on Alcohol Craving and Intimate Partner AggressionK23AA023845 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FLANAGAN, JULIANNE CHRISTINA · 2016 to 2019
$774k
Transdiagnostic Psychotherapy for Veterans with Mood and Anxiety DisordersIK2CX000845 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI GROS, DANIEL F. · 2014 to 2018
–
CSRD VA IK2 CX000845NIAAA NIH HHS K23 AA023845NIDA NIH HHS K02 DA039229NIDA NIH HHS R01 DA030143NIDA NIH HHS R25 DA020537
6 · The paper itself

Abstract

High rates of comorbid posttraumatic stress disorder (PTSD) and substance use disorders (SUD) have been noted in veteran populations. Fortunately, there are a number of evidence-based psychotherapies designed to address comorbid PTSD and SUD. However, treatments targeting PTSD and SUD simultaneously often report high dropout rates. To date, only one study has examined predictors of dropout from PTSD/SUD treatment. To address this gap in the literature, this study aimed to 1) examine when in the course of treatment dropout occurred, and 2) identify predictors of dropout from a concurrent treatment for PTSD and SUD. Participants were 51 male and female veterans diagnosed with current PTSD and SUD. All participants completed at least one session of a cognitive-behavioral treatment (COPE) designed to simultaneously address PTSD and SUD symptoms. Of the 51 participants, 22 (43.1%) dropped out of treatment prior to completing the full 12 session COPE protocol. Results indicated that the majority of dropout (55%) occurred after session 6, with the largest amount of dropout occurring between sessions 9 and 10. Results also indicated a marginally significant relationship between greater baseline PTSD symptom severity and premature dropout. These findings highlight inconsistencies related to timing and predictors of dropout, as well as the dearth of information noted about treatment dropout within PTSD and SUD literature. Suggestions for procedural changes, such as implementing continual symptom assessments during treatment and increasing dialog between provider and patient about dropout were made with the hopes of increasing consistency of findings and eventually reducing treatment dropout.

Indexed as

AdolescentAdultAgedDiagnosis, Dual (Psychiatry)FemaleHumansImplosive TherapyMaleMiddle AgedMilitary PersonnelPatient DropoutsStress Disorders, Post-TraumaticSubstance-Related DisordersUnited StatesVeteransVeterans HealthCOPEDropoutProlonged exposurePTSDSubstance useVeteran

Identifiers

PMID28460246
PMCPMC5507590

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.