ArticleSocial cognitive and affective neuroscience2017
Effects of sensitivity to life stress on uncinate fasciculus segments in early adolescence.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Longitudinal development of the anterior insula-nucleus accumbens white matter pathway through adolescence predicts risk taking in young adulthood.Developmental cognitive neuroscience · 2026Article
- Ultrastructural analysis of human uncinate fasciculus with coherent anti-Stokes Raman spectroscopy.Biophotonics discovery · 2026Article
- A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations.Journal of neurochemistry · 2026Article
- Changes in emotional granularity under a population-level stressor predict social anxiety and depressive symptoms.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Research Review: Assessment of early-life adversity and trauma - cumulative risk and dimensional approaches.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation During Childhood and Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Sex-Specific Vulnerability to Externalizing Problems: Sensitivity to Early Stress and Nucleus Accumbens Activation Over Adolescence.Biological psychiatry · 2025Article
- The growing interdisciplinarity of developmental psychopathology: Implications for science and training.Development and psychopathology · 2024Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.Neuroimage. Reports · 2024Article
- Neighborhood disadvantage and parenting predict longitudinal clustering of uncinate fasciculus microstructural integrity and clinical symptomatology in adolescents.Developmental cognitive neuroscience · 2024Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.medRxiv : the preprint server for health sciences · 2023Article
- Discordance Indices of Stress Sensitivity and Trajectories of Internalizing Symptoms in Adolescence.Research on child and adolescent psychopathology · 2023Article
- Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation.Psychological medicine · 2023Article
- White Matter Microstructural Properties of the Cerebellar Peduncles Predict Change in Symptoms of Psychopathology in Adolescent Girls.Cerebellum (London, England) · 2022Article
- Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Inflammatory cytokines and callosal white matter microstructure in adolescents.Brain, behavior, and immunity · 2022Article
- General additive models address statistical issues in diffusion MRI: An example with clinically anxious adolescents.NeuroImage. Clinical · 2022Article
- Sex differences in myelin content of white matter tracts in adolescents with depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Childhood adversities and the comorbidity between mood and general medical disorders in adults: Results from the WHO World Mental Health Survey Portugal.Brain, behavior, & immunity - health · 2021Article
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Authors and funding
7 authors.
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Abstract
Previous research suggests that exposure to early life stress (ELS) affects the structural integrity of the uncinate fasciculus (UF), a frontolimbic white matter tract that undergoes protracted development throughout adolescence. Adolescence is an important transitional period characterized by the emergence of internalizing psychopathology such as anxiety, particularly in individuals with high levels of stress sensitivity. We examined the relations among sensitivity to ELS, structural integrity of the UF, and anxiety symptoms in 104 early adolescents. We conducted structured interviews to assess exposure to ELS and obtained subjective and objective ratings of stress severity, from which we derived an index of ELS sensitivity. We also acquired diffusion MRI and conducted deterministic tractography to visualize UF trajectories and to compute measures of structural integrity from three distinct segments of the UF: frontal, insular, temporal. We found that higher sensitivity to ELS predicted both reduced fractional anisotropy in right frontal UF and higher levels of anxiety symptoms. These findings suggest that fibers in frontal UF, which are still developing throughout adolescence, are most vulnerable to the effects of heightened sensitivity to ELS, and that reduced structural integrity of frontal UF may underlie the relation between early stress and subsequent internalizing psychopathology.
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