ArticleCerebral cortex (New York, N.Y. : 1991)2017
The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- ARHGAP39 plays an essential role in anxiety-like behavior and stress response.Translational psychiatry · 2026Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse.Brain structure & function · 2024Article
- Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms.Neurobiology of stress · 2024Review
- Pre- versus Post-synaptic Forms of LTP in Two Branches of the Same Hippocampal Afferent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor.Translational psychiatry · 2024Article
- Corticotropin-releasing hormone as a candidate biomarker for parkinsonian disorders.Brain communications · 2024Article
- Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures.Translational psychiatry · 2023Article
- Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice.Nature communications · 2023Article
- Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior.Science advances · 2022Article
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
- Novel types of frequency filtering in the lateral perforant path projections to dentate gyrus.The Journal of physiology · 2022Article
- Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress.Translational psychiatry · 2021Article
- Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance.Biological psychiatry · 2020Review
- Blocking CRH receptors in adults mitigates age-related memory impairments provoked by early-life adversity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Corticotrophin-Releasing Factor Modulates the Facial Stimulation-Evoked Molecular Layer Interneuron-Purkinje Cell Synaptic TransmissionFrontiers in cellular neuroscience · 2020Article
- New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions.The Journal of comparative neurology · 2019Article
- Short-term dynamics of input and output of CA1 network greatly differ between the dorsal and ventral rat hippocampus.BMC neuroscience · 2019Article
- Hyper-diversity of CRH interneurons in mouse hippocampus.Brain structure & function · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Memory is strongly influenced by stress but underlying mechanisms are unknown. Here, we used electrophysiology, neuroanatomy, and network simulations to probe the role of the endogenous, stress-related neuropeptide corticotropin-releasing hormone (CRH) in modulating hippocampal function. We focused on neuronal excitability and the incidence of sharp waves (SPWs), a form of intrinsic network activity associated with memory consolidation. Specifically, we blocked endogenous CRH using 2 chemically distinct antagonists of the principal hippocampal CRH receptor, CRHR1. The antagonists caused a modest reduction of spontaneous excitatory transmission onto CA3 pyramidal cells, mediated, in part by effects on IAHP. This was accompanied by a decrease in the incidence but not amplitude of SPWs, indicating that the synaptic actions of CRH are sufficient to alter the output of a complex hippocampal network. A biophysical model of CA3 described how local actions of CRH produce macroscopic consequences including the observed changes in SPWs. Collectively, the results provide a first demonstration of the manner in which subtle synaptic effects of an endogenously released neuropeptide influence hippocampal network level operations and, in the case of CRH, may contribute to the effects of acute stress on memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.