ArticleAmerican journal of epidemiology2017
Vitamin D and Fracture Risk in Early Childhood: A Case-Control Study.
Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Vitamin D level and fractures in children and adolescents: a systematic review and meta-analysis.Journal of bone and mineral metabolism · 2021Pooled it
- Association of serum 25(OH)Vit-D levels with risk of pediatric fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Does Vitamin D Concentration Matter? The Consequential Effects of Serum Vitamin D Concentration and Supplementation on Paediatric Fracture Risk.Nutrients · 2026Article
- The role of bone health in low-velocity fractures and the effects of obesity on the growing skeleton.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Value-Driven Pediatric Supracondylar Humerus Fracture Care: Implementing Evidence-Based Practices.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Prevalence of inadequate vitamin D level and its predictors in children presenting with torus fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Different Vitamin D Supplementation Strategies in the First Years of Life: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Vitamin D and Forearm Fractures in Children Preliminary Findings: Risk Factors and Correlation between Low-Energy and High-Energy Fractures.Children (Basel, Switzerland) · 2022Article
- Comparison of 25-OH vitamin D levels between children with upper and those with lower extremity fractures: A prospective case-control study.Acta orthopaedica et traumatologica turcica · 2022Article
- Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2021Article
- Preschool Obesity Is Associated With an Increased Risk of Childhood Fracture: A Longitudinal Cohort Study of 466,997 Children and Up to 11 Years of Follow-up in Catalonia, Spain.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Consumption of Cow's Milk in Early Childhood and Fracture Risk: A Prospective Cohort Study.American journal of epidemiology · 2020Article
- Article
- Vitamin D, and Maternal and Child Health.Calcified tissue international · 2020Review
- Vitamin D levels and fracture risk among Hispanic children.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
- Study designs: Part 3 - Analytical observational studies.Perspectives in clinical researchArticle
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the association of vitamin D intake and serum levels with fracture risk in children under 6 years of age. A case-control study was conducted in Toronto, Ontario, Canada. Cases were recruited from the fracture clinic at the Hospital for Sick Children, and matched controls were obtained from the TARGet Kids! primary-care research network. Controls were matched to cases on age, sex, height, and season. Fracture risk was estimated from conditional logistic regression, with adjustment for skin type, fracture history, waist circumference, outdoor free play, neighborhood income, soda consumption, and child's birth weight. A total of 206 cases were recruited during May 2009-April 2013 and matched to 343 controls. Serum 25-hydroxyvitamin D concentration (per 10-nmol/L increment: adjusted odds ratio (aOR) = 0.95, 95% confidence interval (CI): 0.88, 1.03) and intake of cow's milk (<2 cups/day vs. 2 cups/day: aOR = 0.95 (95% CI: 0.60, 1.52); >2 cups/day vs. 2 cups/day: aOR = 1.39 (95% CI: 0.85, 2.23)) were not significantly associated with reduced odds of fracture. A statistically significant association was observed between child use of vitamin D supplements and decreased odds of fracture (yes vs. no: aOR = 0.42, 95% CI: 0.25, 0.69). Vitamin D supplementation, but not serum 25-hydroxyvitamin D level or milk intake, was associated with reduced fracture risk among these healthy young children.
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