Evidence map›Paper›PMID 28459884›Full record

ArticlePloS one2017

Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study.

Eliane A Lucassen, Renée de Mutsert, Saskia le Cessie, Natasha M Appelman-Dijkstra, Frits R Rosendaal, Diana van Heemst, Martin den Heijer, Nienke R Biermasz, NEO study group

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Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eliane A LucassenLaboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden, Leiden University Medical Center, The Netherlands.ORCID http://orcid.org/0000-0003-3590-8732
Renée de MutsertDepartment of Clinical Epidemiology, Leiden, Leiden University Medical Center, The Netherlands.
Saskia le CessieDepartment of Medical Statistics, Leiden, Leiden University Medical Center, The Netherlands.
Natasha M Appelman-DijkstraDepartment of Endocrinology, Leiden, Leiden University Medical Center, The Netherlands.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden, Leiden University Medical Center, The Netherlands.
Diana van HeemstDepartment of Gerontology and Geriatrics, Leiden, Leiden University Medical Center, The Netherlands.
Martin den HeijerDepartment of Clinical Epidemiology, Leiden, Leiden University Medical Centre, The Netherlands.
Nienke R BiermaszDepartment of Endocrinology, Leiden, Leiden University Medical Center, The Netherlands.
NEO study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextSleep deprivation has detrimental metabolic consequences. Osteopenia and sarcopenia usually occur together and increase risk of fractures and disease. Results from studies linking sleep parameters to osteopenia or sarcopenia are scarce and inconsistent.

objectiveTo examine the associations of sleep parameters with osteopenia and sarcopenia, considering the influence of sex and menopause. DESIGN, SETTING AND

participantsCross-sectional analysis of 915 participants (45-65 years, 56% women, BMI 26 (range: 18-56) kg/m2) in the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort study. Sleep duration, quality, and timing were assessed with the Pittsburgh Sleep Quality Index (PSQI); bone mineral density and relative appendicular muscle mass were measured by DXA scans. Linear and logistic regressions were performed to associate sleep parameters to bone mineral density, relative appendicular muscle mass, osteopenia (t-score between -1 and -2.5) and sarcopenia (1 SD below average muscle mass).

resultsAfter adjustment for confounding factors, one unit increase in PSQI score (OR and 95% CI, 1.09, 1.03-1.14), declined self-rated sleep quality (1.76, 1.03-3.01), sleep latency (1.18, 1.06-1.31), and a one hour later sleep timing (1.51, 1.08-2.11), but not sleep duration (1.05, 0.90-1.23), were associated with osteopenia. PSQI score (1.10, 1.02-1.19) was also associated with sarcopenia; OR's of sleep latency and later mid-sleep time with sarcopenia were 1.14 (0.99-1.31) and 1.54 (0.91-2.61), respectively. Associations were somewhat stronger in women and varied per menopausal status.

conclusionsThese results suggest that decreased sleep quality and a later sleep timing are risk factors for osteopenia and sarcopenia in middle aged individuals.

Indexed as

SleepAgedBone DensityBone Diseases, MetabolicCohort StudiesCross-Sectional StudiesFemaleHumansLinear ModelsLogistic ModelsMaleMiddle AgedMuscle, SkeletalNetherlandsOrgan SizeRisk Factors

Identifiers

PMID28459884
PMCPMC5411054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.