ArticlePLoS neglected tropical diseases2017
The clinical features of 590 patients with brucellosis in Xinjiang, China with the emphasis on the treatment of complications.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Medication adherence and its determinants among Brucellosis patients in China: A multi-center follow-up study.PLoS neglected tropical diseases · 2026Article
- Shifting risk profiles in the systemic-to-focal transition of brucellosis: a multicenter analysis of spondyloarthritis development.BMC infectious diseases · 2026Article
- Prevalence and spatial distribution characteristics of human brucellosis in Ningxia from 2010 to 2024.PLoS neglected tropical diseases · 2026Article
- Correlation analysis between the prevalence of hyperuricemia and the triglyceride-glucose index in adult patients with brucellosis.BMC infectious diseases · 2026Article
- Design of a multi-Epitope mRNA vaccine against Brucella type IV secretion system using reverse vaccinology and immunogenicity approaches.Scientific reports · 2025Article
- The continuous expansion and spread of human brucellosis in the Xinjiang Uygur Autonomous Region: evidence from epidemiological and strains' genotyping-based analysis.BMC microbiology · 2025Article
- Epidemiological, clinical, and laboratory characteristics of 581 human brucellosis cases in Xinjiang, China.Frontiers in microbiology · 2025Article
- Incidence and Outcomes of Brucella Endocarditis in a High-Prevalence Area: A Single-Center Study.Journal of epidemiology and global health · 2024Article
- A case of drug fever in the treatment of Brucella arthritis in a child: a case report.BMC infectious diseases · 2024Article
- Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China.Infectious diseases of poverty · 2024Observational
- Prevalence ofHealth science reports · 2023Article
- Article
- Development and validation of a diagnostic model for differentiating tuberculous spondylitis from brucellar spondylitis using machine learning: A retrospective cohort study.Frontiers in surgery · 2022Article
- Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China.International journal of general medicine · 2022Article
- The current therapeutical strategies in human brucellosis.Infection · 2021Review
- Brucella prostatic abscess: a retrospective study of eight cases and a literature review.The Journal of international medical research · 2021Review
- Comparative Evaluation of Nested Polymerase Chain Reaction for Rapid Diagnosis of Human Brucellosis.Archives of Razi Institute · 2021Article
- A case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3.BMC infectious diseases · 2021Article
- Serosurvey and Risk Factors Associated withPathogens (Basel, Switzerland) · 2021Article
- Prevalence, distribution and risk factors for brucellosis infection in goat farms in Ningxiang, China.BMC veterinary research · 2021Article
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7 authors.
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Abstract
backgroundThis study aims to analyze the clinical characteristics and treatment outcomes of 590 patients with brucellosis in Xinjiang, China. METHODOLOGY AND PRINCIPAL
findingsThe clinical characteristics, laboratory findings, complications and prognosis of 590 patients infected with brucellosis were retrospectively analyzed. These patients had a mean age of 44.24 ± 15.83 years with 60.5% having a history of close contacting with cattle and sheep. Of them, 53.6% (316 /590) were in acute phase and 21.5% were in chronic phase. Agglutination test showed 98.5% positive with 34% blood culture positive of Brucella. The major symptoms were fatigue (91%), hyperhidrosis(88.1%), fever(86.9%), and joint pain(81%) with 29.8% having enlarged liver, 26.1% having enlarged spleen and 23.2% having osteoarticular complications. Combination of doxycycline plus rifampicin for 12 weeks was an effective regimen for patients without complications. The 3-drug regimen (doxycycline+rifampicin+levofloxacin) for 12 weeks was recommended for these with complications. There were 6 patients died (1.02%) with overall relapse rate of 5.98%.
conclusionsBrucellosis is mostly associated with contacting with domestic animal production in Xinjiang, China. Clinical symptoms include fever, fatigue, hyperhidrosis, and joint pain with common complication of osteoarticular involvement. Three-drug-regimen of doxycycline+rifampicin+levofloxacin for 12 weeks was effective for these patients with complications.
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