ArticleJournal of the American Chemical Society2017
Photostable Ratiometric Pdot Probe for in Vitro and in Vivo Imaging of Hypochlorous Acid.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Construction of an activatable ratiometric fluorescent nanoprobe for HClO detection and imaging in acute kidney injury models.RSC advances · 2026Article
- Stimuli-Responsive Aggregation-Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications.Small science · 2026Review
- Creating Semiconducting Polymer Dots with Enhanced Performance Through a Simple Mixed Antisolvent Approach.Biosensors · 2026Article
- A Phenazine-Based Fluorescent Probe with Imidazoline-2-Thione for Rapid and Selective Detection of HOCl in Living Cells.Journal of fluorescence · 2026Article
- Recent Progress in Small Molecule-Based Chemiluminescent Probes for Reactive Oxygen and Nitrogen Species.Chemical & biomedical imaging · 2025Review
- A chemically modified DNAzyme-based electrochemical sensor for binary and highly sensitive detection of reactive oxygen species.Chemical science · 2025Article
- BODIPY-Based Ratiometric Fluorescent Probe for Sensing Peroxynitrite in Inflammatory Cells and Tissues.Biosensors · 2024Article
- Smart molecular probes with controllable photophysical property for smart medicine.Smart molecules : open access · 2024Review
- Salivary diagnostics: opportunities and challenges.Theranostics · 2024Review
- Brightness of fluorescent organic nanomaterials.Chemical Society reviews · 2023Review
- BODIPY-based near-infrared semiconducting polymer dot for selective yellow laser-excited cell imaging.RSC advances · 2023Article
- Design and Synthesis of Novel Fluorescent Probe Based on Cyanobiphenyl and its Application in Detection of Hypochlorite.Journal of fluorescence · 2023Article
- High-Precision Mapping of Membrane Proteins on Synaptic Vesicles using Spectrally Encoded Super-Resolution Imaging.Angewandte Chemie (International ed. in English) · 2023Article
- Semiconducting Polymer Dots for Point-of-Care Biosensing and In Vivo Bioimaging: A Concise Review.Biosensors · 2023Review
- BODIPY-Based Fluorescent Probes for Selective Visualization of Endogenous Hypochlorous Acid in Living Cells via Triazolopyridine Formation.Biosensors · 2022Article
- TADF-based NIR-II semiconducting polymer dots forChemical science · 2022Article
- Gadolinium and Polythiophene Functionalized Polyurea Polymer Dots as Fluoro-Magnetic Nanoprobes.Nanomaterials (Basel, Switzerland) · 2022Article
- Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives.Nature communications · 2022Article
- Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases.Biosensors · 2021Review
- Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe.Chemical science · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Developing probes for the detection of reactive oxygen species (ROS), a hallmark of many pathophysiological process, is imperative to both understanding the precise roles of ROS in many life-threatening diseases and optimizing therapeutic interventions. We herein report an all-in-one fluorescent semiconducting polymer based far-red to near-infrared (NIR) Pdot nanoprobe for the ratiometric detection of hypochlorous acid (HOCl). The fabrication takes the advantage of flexible polymer design by incorporating target-sensitive and target-inert fluorophores into a single conjugated polymer to avoid leakage or differential photobleaching problems existed in other nanoprobes. The obtained nanoprobe has improved performance in HOCl sensing, such as high brightness, ideal far-red to NIR optical window, excellent photostability, self-referenced ratiometric response, fast response, and high selectivity. The dual-emission property allows the sensitive imaging of HOCl fluctuations produced in living macrophage cells and peritonitis of living mice with high contrast. This study not only provides a powerful and promising nanoprobe to be potentially used in the investigations of in situ HOCl status of diseases in living systems but also puts forward the design strategy of a new category of ratiometric fluorescent probes facilitating precise and reliable measurement in biological systems.
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Registered trials
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