ArticleOncogene2017
Insulin resistance in vascular endothelial cells promotes intestinal tumour formation.
Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- The Oncogenic Burden of Obesity: Mechanistic Links Between Adiposity and Gastrointestinal Cancers-A Comprehensive Narrative Review.Biomedicines · 2025Review
- Association of the triglyceride-glucose index with the occurrence and recurrence of colorectal adenomas: a retrospective study from China.BMC public health · 2024Article
- Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation.Cancer biology & medicine · 2023Review
- The lncRNA Tincr Regulates the Abnormal Differentiation of Intestinal Epithelial Stem Cells in the Diabetic StateCurrent stem cell research & therapy · 2023Article
- Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer.BMC cancer · 2022Article
- Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk.Frontiers in endocrinology · 2022Article
- The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells.American journal of physiology. Endocrinology and metabolism · 2021Article
- Rspo3 regulates the abnormal differentiation of small intestinal epithelial cells in diabetic state.Stem cell research & therapy · 2021Article
- [Expression of tumor-associated vascular insulin receptor in colorectal cancer and its relationship with tumor pathological features].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Article
- Triglyceride-glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study.BMC endocrine disorders · 2020Article
- Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review).Oncology reports · 2019Review
- Endothelial cells in colorectal cancer.World journal of gastrointestinal oncology · 2019Review
- Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells.BMC cancer · 2019Article
- Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer.Oncology letters · 2019Article
- Insulin transport across the blood-brain barrier can occur independently of the insulin receptor.The Journal of physiology · 2018Article
- Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.Endocrine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 5 countries.
Funding
Abstract
The risk of several cancers, including colorectal cancer, is increased in patients with obesity and type 2 diabetes, conditions characterised by hyperinsulinaemia and insulin resistance. Because hyperinsulinaemia itself is an independent risk factor for cancer development, we examined tissue-specific insulin action in intestinal tumour formation. In vitro, insulin increased proliferation of intestinal tumour epithelial cells by almost two-fold in primary culture of tumour cells from Apc
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.