ArticleOncogene2017
INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma.
Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.Cell reports. Medicine · 2024Pooled it
- Eribulin-induced resolution of high-risk basal cell carcinoma: implications for microtubule-targeting agents in BCC management: a case report.Acta oncologica (Stockholm, Sweden) · 2026Article
- Genome-based analysis of the genetic pattern of black sheep in Qira sheep.BMC genomics · 2025Article
- Article
- Immunomodulatory potential of primary cilia in the skin.Frontiers in immunology · 2024Review
- Gene and pathway based burden analyses in familial lymphoid cancer cases: Rare variants in immune pathway genes.PloS one · 2023Article
- Article
- CPLANE Complex and Ciliopathies.Biomolecules · 2022Review
- Article
- Clinical Implications of Primary Cilia in Skin Cancer.Dermatology and therapy · 2020Review
- Hexa-Longin domain scaffolds for inter-Rab signalling.Bioinformatics (Oxford, England) · 2020Article
- Freeing the brake: Proliferation needs primary cilium to disassemble.Journal of biosciences · 2020Review
- CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.Frontiers in cell and developmental biology · 2020Article
- Mixed signals from the cell's antennae: primary cilia in cancer.EMBO reports · 2018Review
- The regulation of cilium assembly and disassembly in development and disease.Development (Cambridge, England) · 2018Review
- Ciliary signalling in cancer.Nature reviews. Cancer · 2018Review
- The primary cilium - once a "rudimentary" organelle that is now a ubiquitous sensory cellular structure involved in many pathological disorders.Journal of cell communication and signaling · 2018Article
- EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Inturned (INTU), a cilia and planar polarity effector, performs prominent ciliogenic functions during morphogenesis, such as in the skin. INTU is expressed in adult tissues but its role in tissue maintenance is unknown. Here, we report that the expression of the INTU gene is aberrantly elevated in human basal cell carcinoma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) signaling. Disrupting Intu in an oncogenic mutant Smo (SmoM2)-driven BCC mouse model prevented the formation of BCC through suppressing primary cilia formation and Hh signaling, suggesting that Intu performs a permissive role during BCC formation. INTU is essential for intraflagellar transport A complex assembly during ciliogenesis. To further determine whether Intu is directly involved in the activation of Hh signaling downstream of ciliogenesis, we examined the Hh signaling pathway in mouse embryonic fibroblasts, which readily responds to the Hh pathway activation. Depleting Intu blocked Smo agonist-induced Hh pathway activation, whereas the expression of Gli2ΔN, a constitutively active Gli2, restored Hh pathway activation in Intu-deficient cells, suggesting that INTU functions upstream of Gli2 activation. In contrast, overexpressing Intu did not promote ciliogenesis or Hh signaling. Taken together, data obtained from this study suggest that INTU is indispensable during BCC tumorigenesis and that its aberrant upregulation is likely a prerequisite for primary cilia formation during Hh-dependent tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.