ArticleNature immunology2017
Mice deficient in NRROS show abnormal microglial development and neurological disorders.
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 72 citations in OpenAlex.
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- Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice.Nature communications · 2024Article
- The molecular determinants of microglial developmental dynamics.Nature reviews. Neuroscience · 2024Review
- Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis.Research square · 2024Article
- A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.Cell reports · 2024Article
- APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.Nature immunology · 2023Article
- Microglia and Brain Disorders: The Role of Vitamin D and Its Receptor.International journal of molecular sciences · 2023Review
- Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models.bioRxiv : the preprint server for biology · 2023Article
- Mechanisms of myeloid cell entry to the healthy and diseased central nervous system.Nature immunology · 2023Review
- Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome.Pain research & management · 2023Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia and other tissue-resident macrophages within the central nervous system (CNS) have essential roles in neural development, inflammation and homeostasis. However, the molecular pathways underlying their development and function remain poorly understood. Here we report that mice deficient in NRROS, a myeloid-expressed transmembrane protein in the endoplasmic reticulum, develop spontaneous neurological disorders. NRROS-deficient (Nrros
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