ArticleLaryngoscope investigative otolaryngology2016
Innate immunity and chronic rhinosinusitis: What we have learned from animal models.
Article in Laryngoscope investigative otolaryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05365841 (Role of Epithelial Barrier Integrity in Biologic Treatment Response of Severe Asthmatics With/Out Chronic Rhinosinusitis With Nasal Polyps), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Epithelial Barrier Integrity in Biologic Treatment Response of Severe Asthmatics With/Out Chronic Rhinosinusitis With Nasal Polyps (CRSwNP). Can Shedding of Epithelial Barrier Proteins be Used as Biomarker in Severe Asthma With/Out CRSwNP Management?
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Sinonasal Outcomes Using Oral Corticosteroids in Patients with Chronic Rhinosinusitis with Nasal Polyps and Positive Sinonasal Cultures.International archives of otorhinolaryngology · 2023Article
- Serum, Whole Blood, Hair, and Mucosal Essential Trace Element and Mineral Levels in Children with Verified Chronic Rhinosinusitis Undergoing Functional Endoscopic Sinus Surgery.Biological trace element research · 2021Article
- Unilateral Intervention in the Sinuses of Rabbits Induces Bilateral Inflammatory and Microbial Changes.Frontiers in cellular and infection microbiology · 2021Article
- Epithelial barriers in allergy and asthma.The Journal of allergy and clinical immunology · 2020Review
- The Microbiome and Chronic Rhinosinusitis.Immunology and allergy clinics of North America · 2020Review
- Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.Allergy, asthma & immunology research · 2020Review
- Type 2/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model.Allergy · 2019Article
- Deletion of Nrf2 enhances susceptibility to eosinophilic sinonasal inflammation in a murine model of rhinosinusitis.International forum of allergy & rhinology · 2019Article
- Cancer risk in chronic rhinosinusitis: a propensity score matched case-control cohort study.American journal of translational research · 2019Article
- Chronic rhinosinusitis control from the patient and physician perspectives.Laryngoscope investigative otolaryngology · 2018Article
- Sinuses and Common Rhinologic Conditions.The Medical clinics of North America · 2018Review
- Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Impact of odontogenic chronic rhinosinusitis on general health-related quality of life.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- A contemporary analysis of clinical and demographic factors of chronic rhinosinusitis patients and their association with disease severity.Irish journal of medical science · 2018Article
- A synthetic glycosaminoglycan reduces sinonasal inflammation in a murine model of chronic rhinosinusitis.PloS one · 2018Article
- The Role of the Sinonasal Epithelium in Allergic Rhinitis.Otolaryngologic clinics of North America · 2017Review
- Airborne Particulate Matter Induces Nonallergic Eosinophilic Sinonasal Inflammation in Mice.American journal of respiratory cell and molecular biology · 2017Article
- Systematic elucidation of the cross-omics regulatory network in chronic rhinosinusitis: the LAT-IL23R metabolic axis.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveChronic rhinosinusitis (CRS) is a heterogeneous and multifactorial disease characterized by dysregulated inflammation. Abnormalities in innate immune function including sinonasal epithelial cell barrier function, mucociliary clearance, response to pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs), and the contribution of innate immune cells will be highlighted in this review. DATA SOURCES: PubMed literature review. REVIEW
methodsA review of the literature was conducted to determine what we have learned from animal models in relation to innate immunity and chronic rhinosinusitis.
resultsDysregulation of innate immune mechanisms including sinonasal barrier function, mucociliary clearance, PAMPs, and innate immune cells such as eosinophils, mast cells, and innate lymphoid cells may contribute to CRS pathogenesis. Sinonasal inflammation has been studied using mouse, rat, rabbit, pig, and sheep explant or
conclusionAnimal models have shed light as to the potential contribution of dysregulated innate immunity in chronic sinonasal inflammation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.