Evidence map›Paper›PMID 28458991›Full record

ArticleCurrent stem cell reports2017

Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the

Elizabeth T Ables, Daniela Drummond-Barbosa

Open access · greenAbstract read
In one paragraph

Article in Current stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Ovary-Derived Signals Align Protein Appetite with Oogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
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  12. Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. TheG3 (Bethesda, Md.) · 2020
    Article
  14. Article
  15. Article
  16. Regulation of Drosophila germline stem cells.Current opinion in cell biology · 2019
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Elizabeth T AblesDepartment of Biology, East Carolina University, Greenville, NC 27858, USA.
Daniela Drummond-BarbosaDepartment of Biochemistry and Molecular Biology, Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
East Carolina University · USJohns Hopkins University · US

Funding

Nutrient Sensing in Adipocytes and the Control of Oogenesis in DrosophilaR01GM069875 · NIGMS · VANDERBILT UNIVERSITY · PI DRUMMOND-BARBOSA, DANIELA · 2005 to 2020
$5.2M
Molecular mechanisms of oocyte development in DrosophilaR15GM117502 · NIGMS · EAST CAROLINA UNIVERSITY · PI ABLES, ELIZABETH TWEEDIE · 2016 to 2023
$1.4M
NIGMS NIH HHS R01 GM069875NIGMS NIH HHS R15 GM117502
6 · The paper itself

Abstract

purpose of reviewStem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the RECENT

findingsStem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. SUMMARY: Hormones are inextricably linked to animal physiology, and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology, and for informing new therapeutic interventions against cancers or for regenerative medicine.

Indexed as

cell fatedifferentiationecdysonegerm cellsgermlinenuclear hormone receptoroocyteoogenesisself-renewal

Identifiers

PMID28458991
PMCPMC5407287
OpenAlexW2583920556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.