Evidence map›Paper›PMID 28458959›Full record

ArticlePlastic and reconstructive surgery. Global open2017

Preoperative Radiotherapy Is Not Associated with Increased Post-mastectomy Short-term Morbidity: Analysis of 77,902 Patients.

Pablo A Baltodano, Myrna Eliann Reinhardt, José M Flores, Francis M Abreu, Anmol Chattha, Lyonell Kone, Carisa M Cooney, Michele A Manahan, Richard C Zellars, Gedge D Rosson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pablo A BaltodanoDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Myrna Eliann ReinhardtDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
José M FloresDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Francis M AbreuDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Anmol ChatthaDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Lyonell KoneDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Carisa M CooneyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Michele A ManahanDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Richard C ZellarsDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Gedge D RossonDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD; Department of Plastic and Reconstructive Surgery, Albany Medical Center, Albany, NY; and Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeoadjuvant radiotherapy (NRT) enhances breast-conserving surgery outcomes, reducing local recurrence of breast cancer and increasing median survival. However, its effect on postoperative morbidity remains under-studied. We sought to assess the impact of NRT on 30-day postoperative morbidity after mastectomy.

methodsWe analyzed data from women undergoing mastectomy (with or without immediate reconstruction) using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) 2005-2011 datasets. ACS-NSQIP is a prospective, risk-adjusted, outcomes-based registry. Data included demographic and perioperative factors. Outcomes studied included surgical site (wound and prosthesis/flap complications), systemic (cardiac, respiratory, neurological, urinary, and venous thromboembolism events), and overall morbidity. Logistic regression was used to estimate the unadjusted odds ratio (uOR) and adjusted odds ratio (aOR) between NRT and postoperative 30-day morbidity.

resultsThe study population included 77,902 women, of which 61,039 (78.4%) underwent mastectomy only and 16,863 (21.6%) underwent mastectomy with immediate breast reconstruction. NRT was administered to 266 (0.4%) mastectomy-only and 75 (0.4%) immediate breast reconstruction patients. In the mastectomy-only group, there were no significant differences in the rates of postoperative surgical site morbidity (aOR = 1.41; 95% confidence interval (CI): 0.76-2.63;

conclusionsThis study suggests that NRT is not associated with significantly higher 30-day postoperative complications among breast cancer patients undergoing mastectomy with or without immediate breast reconstruction.

Identifiers

PMID28458959
PMCPMC5404430
OpenAlexW2597252734

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.