Evidence map›Paper›PMID 28458925›Full record

ArticleNeural plasticity2017

Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease.

Lingyan Xu, Zhiyun Ren, Frances E Chow, Richard Tsai, Tongzheng Liu, Flavio Rizzolio, Silvia Boffo, Yungen Xu, Shaohui Huang, Carol F Lippa and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Pin1 and Alzheimer's disease.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
  6. Article
  7. The regulatory role of Pin1 in neuronal death.Neural regeneration research · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Molecular crosstalk between cancer and neurodegenerative diseases.Cellular and molecular life sciences : CMLS · 2020
    Review
  12. Downregulation of miR-33 Has Protective Effect Against Aβ₂₅₋₃₅-Induced Injury in SH-SH-SY5Y Cells.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  13. Review
  14. Peptidyl-ProlylFrontiers in cell and developmental biology · 2020
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Lingyan XuJiangsu Key Laboratory for Functional Substance of Chinese Medicine, Department of Biopharmaceutics and Food Science, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhiyun RenJiangsu Key Laboratory for Functional Substance of Chinese Medicine, Department of Biopharmaceutics and Food Science, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Frances E ChowDepartment of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Richard TsaiDepartment of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Tongzheng LiuDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Flavio RizzolioSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.
Silvia BoffoSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.
Yungen XuDepartment of Medicinal Chemistry, China Pharmaceutical University, Nanjing 21009, China.
Shaohui HuangDepartment of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Carol F LippaDepartment of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.ORCID 0000-0001-5960-6048
Yuesong GongJiangsu Key Laboratory for Functional Substance of Chinese Medicine, Department of Biopharmaceutics and Food Science, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID 0000-0003-4191-6405
Drexel University · USNanjing University of Chinese Medicine · CNCa' Foscari University of Venice · ITChina Pharmaceutical University · CNMayo Clinic in Arizona · USUniversity of Pennsylvania · US

Funding

Pathogenic Template of Natural Oligomer of Beta-Amyloid in Alzheimer's DiseaseR21AG031388 · NIA · DREXEL UNIVERSITY · PI GONG, YUESONG · 2008 to 2009
$319k
NIA NIH HHS R21 AG031388
6 · The paper itself

Abstract

Synaptic loss is the structural basis for memory impairment in Alzheimer's disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as

Indexed as

Neuronal PlasticityAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCells, CulturedDendritic SpinesDisks Large Homolog 4 ProteinHumansMice, Inbred C57BLMice, KnockoutMice, TransgenicNerve Tissue ProteinsNIMA-Interacting Peptidylprolyl IsomeraseAmyloid beta-PeptidesDisks Large Homolog 4 ProteinDLG4 protein, humanMAPT protein, humanNerve Tissue ProteinsNIMA-Interacting Peptidylprolyl IsomeraseNR1 NMDA receptorPIN1 protein, humanReceptors, N-Methyl-D-AspartateSHANK3 protein, humantau ProteinsUbiquitin

Identifiers

PMID28458925
PMCPMC5385220
OpenAlexW2601983531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.