Evidence map›Paper›PMID 28458916›Full record

ArticleVirus evolution2017

Transmission patterns and evolution of respiratory syncytial virus in a community outbreak identified by genomic analysis.

Charles N Agoti, Patrick K Munywoki, My V T Phan, James R Otieno, Everlyn Kamau, Anne Bett, Ivy Kombe, George Githinji, Graham F Medley, Patricia A Cane and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Virus evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05017519 (Epidemiology and Transmission of Streptococcus Pneumoniae and Respiratory Syncytial Virus in Children and Elderly), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05017519 unknown statusnot on this mapstarted 2021, after this paper: background citation

Epidemiology and Transmission of Streptococcus Pneumoniae and Respiratory Syncytial Virus in Children and Elderly: a Household-based Prospective Cohort Study

Typeobservational_patient_registrySponsorMackay Memorial HospitalRan2021 to 2026Enrolled240ConditionsStreptococcus Pneumoniae Infection, Respiratory Syncytial Virus Infections
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  8. Genomic characterisation of respiratory syncytial virus: a novel system for whole genome sequencing and full-length G and F gene sequences.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
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  9. Review
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  17. Primary and Repeated Respiratory Viral Infections Among Infants in Rural Nepal.Journal of the Pediatric Infectious Diseases Society · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Charles N AgotiEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
Patrick K MunywokiEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
My V T PhanThe Wellcome Trust Sanger Institute, Cambridge, UK.
James R OtienoEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
Everlyn KamauEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
Anne BettEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
Ivy KombeEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
George GithinjiEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
Graham F MedleyDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Patricia A CaneVirus Reference Department, Public Health England, London, UK.
Paul KellamThe Wellcome Trust Sanger Institute, Cambridge, UK.
Matthew CottenThe Wellcome Trust Sanger Institute, Cambridge, UK.
D James NokesEpidemiology and Demography Department, Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Collaborative Programme, Kilifi, Kenya.
Kenya Medical Research Institute · KEWellcome Sanger Institute · GBImperial College London · GBLondon School of Hygiene & Tropical Medicine · GBPublic Health England · GBUniversity of Warwick · GB

Funding

Medical Research Council MC_UU_12014/12Wellcome Trust
6 · The paper itself

Abstract

Detailed information on the source, spread and evolution of respiratory syncytial virus (RSV) during seasonal community outbreaks remains sparse. Molecular analyses of attachment (G) gene sequences from hospitalized cases suggest that multiple genotypes and variants co-circulate during epidemics and that RSV persistence over successive seasons is characterized by replacement and multiple new introductions of variants. No studies have defined the patterns of introduction, spread and evolution of RSV at the local community and household level. We present a whole genome sequence analysis of 131 RSV group A viruses collected during 6-month household-based RSV infection surveillance in Coastal Kenya, 2010 within an area of 12 km

Indexed as

community transmissionfull-genome sequencinghousehold transmissionRSVWAIFW

Identifiers

PMID28458916
PMCPMC5399923
OpenAlexW2592943979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.