Evidence map›Paper›PMID 28458669›Full record

ArticleFrontiers in immunology2017

Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients.

Samuel C C Chiang, Stephanie M Wood, Bianca Tesi, Himmet Haluk Akar, Waleed Al-Herz, Sandra Ammann, Fatma Burcu Belen, Umran Caliskan, Zühre Kaya, Kai Lehmberg and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Spectrum ofJournal of medical genetics · 2024
    Review
  4. Review
  5. CD8Advances in experimental medicine and biology · 2024
    Review
  6. The lysosomal trafficking regulator is necessary for normal wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Lysosomal size matters.Traffic (Copenhagen, Denmark) · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 6 countries.

Samuel C C ChiangCenter for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Stephanie M WoodCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Bianca TesiCenter for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Himmet Haluk AkarFaculty of Medicine, Department of Pediatric Immunology, Erciyes University, Kayseri, Turkey.
Waleed Al-HerzDepartment of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Sandra AmmannCenter for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Fatma Burcu BelenIzmir Katip Celebi University Medical Faculty, Department of Pediatric Hematology and Oncology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
Umran CaliskanMeram Faculty of Medicine, Department of Pediatric Hematology, Necmettin Erbakan University, Konya, Turkey.
Zühre KayaPediatric Hematology Unit of the Department of Pediatrics, Medical School of Gazi University, Ankara, Turkey.
Kai LehmbergDepartment of Pediatric Hematology and Oncology, Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Turkan PatirogluFaculty of Medicine, Department of Pediatric Immunology, Erciyes University, Kayseri, Turkey.
Huseyin TokgozMeram Faculty of Medicine, Department of Pediatric Hematology, Necmettin Erbakan University, Konya, Turkey.
Ayşegül ÜnüvarDivision of Pediatric Hematology and Oncology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Wendy J IntroneOffice of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jan-Inge HenterChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden.
Magnus NordenskjöldClinical Genetics Unit, Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Hans-Gustaf LjunggrenCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Marie MeethsChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden.
Stephan EhlCenter for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Konrad KrzewskiReceptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Yenan T BrycesonCenter for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Karolinska Institutet · SEErciyes University · TRNecmettin Erbakan University · TRGazi University · TRIstanbul University · TRIzmir Kâtip Çelebi University · TRKarolinska University Hospital · SEKuwait University · KWNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USUniversity Medical Center Freiburg · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Freiburg · DE

Funding

Regulation of lytic granule exocytosis in Natural Killer (NK) CellsZIAAI000962 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI COLIGAN, JOHN · 2009 to 2018
$2.5M
Analysis of NK Cell Function in Lysosome Storage DisordersZIAAI001174 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI COLIGAN, JOHN · 2012 to 2018
$1.0M
6 · The paper itself

Abstract

Chediak-Higashi syndrome (CHS) is caused by autosomal recessive mutations in

Indexed as

Chediak–Higashi syndromecytotoxic T cellsendosomesexocytosislysosomeslytic granule polarizationNK cells

Identifiers

PMID28458669
PMCPMC5394158
OpenAlexW2605842510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.