ArticleInternational journal of nanomedicine2017
A sensitive and selective electrochemical biosensor for the determination of beta-amyloid oligomer by inhibiting the peptide-triggered in situ assembly of silver nanoparticles.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Gold Nanoparticle-Decorated Catalytic Micromotor-Based Aptassay for Rapid Electrochemical Label-Free Amyloid-β42 Oligomer Determination in Clinical Samples from Alzheimer's Patients.Analytical chemistry · 2024Article
- Impact of nanotechnology on conventional and artificial intelligence-based biosensing strategies for the detection of viruses.Discover nano · 2023Review
- Peptide-Coated Bacteriorhodopsin-Based Photoelectric Biosensor for Detecting Rheumatoid Arthritis.Biosensors · 2023Article
- Functional Nanomaterials for the Diagnosis of Alzheimer's Disease: Recent Progress and Future Perspectives.Advanced functional materials · 2023Article
- Electrochemical nanobiosensors equipped with peptides: a review.Mikrochimica acta · 2022Review
- Detection of Amyloid-β(1-42) Aggregation With a Nanostructured Electrochemical Sandwich Immunoassay Biosensor.Frontiers in bioengineering and biotechnology · 2022Article
- In Situ Assembly of Nanomaterials and Molecules for the Signal Enhancement of Electrochemical Biosensors.Nanomaterials (Basel, Switzerland) · 2021Review
- Technological advances in electrochemical biosensors for the detection of disease biomarkers.Biomedical engineering letters · 2021Review
- Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications.Materials (Basel, Switzerland) · 2021Review
- Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges.Journal of nanobiotechnology · 2021Review
- Deciphering the Disaggregation Mechanism of Amyloid Beta Aggregate by 4-(2-Hydroxyethyl)-1-Piperazinepropanesulfonic Acid Using Electrochemical Impedance Spectroscopy.Sensors (Basel, Switzerland) · 2021Article
- Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer's Disease in Blood.Frontiers in molecular neuroscience · 2021Review
- Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing.Molecules (Basel, Switzerland) · 2020Review
- Bleomycin modulates amyloid aggregation in β-amyloid and hIAPP.RSC advances · 2020Article
- Au/NiFeNanoscale advances · 2020Article
- A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers.International journal of nanomedicine · 2018Article
- Emerging Biosensing Technologies for Neuroinflammatory and Neurodegenerative Disease Diagnostics.Frontiers in molecular neuroscience · 2018Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Soluble beta-amyloid (Aβ) oligomer is believed to be the most important toxic species in the brain of Alzheimer's disease (AD) patients. Thus, it is critical to develop a simple method for the selective detection of Aβ oligomer with low cost and high sensitivity. In this paper, we report an electrochemical method for the detection of Aβ oligomer with a peptide as the bioreceptor and silver nanoparticle (AgNP) aggregates as the redox reporters. This strategy is based on the conversion of AgNP-based colorimetric assay into electrochemical analysis. Specifically, the peptide immobilized on the electrode surface and presented in solution triggered together the in situ formation of AgNP aggregates, which produced a well-defined electrochemical signal. However, the specific binding of Aβ oligomer to the immobilized peptide prevented the in situ assembly of AgNPs. As a result, a poor electrochemical signal was observed. The detection limit of the method was found to be 6 pM. Furthermore, the amenability of this method for the analysis of Aβ oligomer in serum and artificial cerebrospinal fluid (aCSF) samples was demonstrated.
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