Evidence map›Paper›PMID 28458531›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2017

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD.

Samantha J Thulborn, Madiha Dilpazir, Koirobi Haldar, Vijay Mistry, Christopher E Brightling, Michael R Barer, Mona Bafadhel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Samantha J ThulbornRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford.
Madiha DilpazirDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford.
Koirobi HaldarDepartment of Immunity, Infection & Inflammation, University of Leicester, Leicester, UK.
Vijay MistryDepartment of Immunity, Infection & Inflammation, University of Leicester, Leicester, UK.
Christopher E BrightlingDepartment of Immunity, Infection & Inflammation, University of Leicester, Leicester, UK.
Michael R BarerDepartment of Immunity, Infection & Inflammation, University of Leicester, Leicester, UK.
Mona BafadhelRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford.
University of Leicester · GBUniversity of Oxford · GBOxford Brookes University · GB

Funding

Department of Health PDF-2013-06-052Medical Research Council G0601369Medical Research Council G0801980
6 · The paper itself

Abstract

backgroundPentraxin 3 (PTX3) is an acute phase protein, involved in antibacterial resistance. Recent studies have shown PTX3 levels to be elevated in the presence of a bacterial infection and in a murine sepsis model.

objectiveWe aim to investigate if sputum PTX3 can be used as a biomarker for bacterial infection in subjects with COPD. MATERIALS AND

methodsSputum samples from 142 COPD patients (102 men) with a mean (range) age of 69 years (45-85) and mean (SD) post-bronchodilator percentage predicted forced expiratory volume in 1 second (FEV

resultsThe geometric mean (95% CI) PTX3 level at stable state was 50.5 ng/mL (41.4-61.7). PTX3 levels correlated with absolute neutrophil count in sputum (

conclusionPTX3 is associated with bacterial infection in patients with COPD, but its utility as a biomarker for identifying a bacteria-associated exacerbation warrants further studies.

Indexed as

AgedAged, 80 and overArea Under CurveBacterial InfectionsBacterial LoadBiomarkersC-Reactive ProteinDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleForced Expiratory VolumeHumansLongitudinal StudiesLungMaleMiddle AgedBiomarkersC-Reactive ProteinPentraxinsSerum Amyloid P-ComponentinfectionsputumTNF-inducible gene 14 protein

Identifiers

PMID28458531
PMCPMC5402921
OpenAlexW2606660663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.