Evidence map›Paper›PMID 28458419›Full record

ArticleIndian journal of pharmacology

Palliative effects of lutein intervention in gamma-radiation-induced cellular damages in Swiss albino mice.

Vidya Vasudeva, Yogish Somayaji Tenkanidiyoor, Vishakh Radhakrishna, Pooja Shivappa, Srikanth Patil Lakshman, Ronald Fernandes, Krishna Ananthapura Patali

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Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vidya VasudevaResearch Scholar, Central Research Laboratory, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Yogish Somayaji TenkanidiyoorResearch Scholar, Central Research Laboratory, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Vishakh RadhakrishnaResearch Scholar, Central Research Laboratory, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Pooja ShivappaResearch Scholar, Central Research Laboratory, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Srikanth Patil LakshmanDepartment of Physiology, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Ronald FernandesDepartment of Biochemistry, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Nitte University, Mangalore, Karnataka, India.
Krishna Ananthapura PataliDepartment of Physiology, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
K S Hegde Medical Academy · INNitte University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRadiation-induced hematological, biochemical, and cytogenetic damages to the normal cells are major concerns in the field of radiotherapy. The carotenoids and their derivatives have been the source of antioxidants with wide range of medicinal applications. The objective is to evaluate the protective effects of lutein, a carotenoid, against radiation-induced cellular and tissue damages.

methodsSwiss albino mice were grouped into 5, 50, 250, and 500 mg/kg b.wt. of lutein treatment groups, a sham and vehicle control group. The groups were irradiated with a lethal dose of 10 Gy y'-radiation. The mortality was recorded for 30 days to optimize the protective dose against radiation. The mice were administered with the compound orally for 15 consecutive days and irradiated with a sublethal dose of 6Gy. The hematological changes in blood and antioxidant parameters were determined in liver, kidney homogenates, and hemolysate/serum. The hematological parameters were recorded using an automated cell counter. The antioxidants such as malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase were spectrophotometrically determined.

resultsThe red blood cell, white blood cell count, lymphocyte count, hemoglobin, platelet levels, and hematocrit value were found to be decreased in the irradiated groups. Lutein pretreatment maintains near-normal levels of these parameters indicating resistance/recovery from the radiation-induced damages. The antioxidant levels were found to be reduced in all the irradiated groups. However, lutein pretreatment (50 mg/kg b.wt.) has increased the catalase activity of hemolysate. Lutein pretreatment has reduced the MDA levels in hemolysate, when administered at doses of 5, 250, and 500 mg/kg b.wt. in comparison to its control.

conclusionThe study demonstrates the radioprotective potential of lutein by maintaining the hematological and antioxidant homeostasis.

Indexed as

AnimalsAntioxidantsDose-Response Relationship, DrugGamma RaysGlutathioneKidneyLiverLuteinMalondialdehydeMiceRadiation InjuriesRadiation-Protective AgentsAntioxidantsGlutathioneLuteinMalondialdehydeRadiation-Protective AgentsAntioxidantcarotenoidhematoprotectivelipid peroxidationluteinradioprotection

Identifiers

PMID28458419
PMCPMC5351234
OpenAlexW2591591011

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.