ArticleThe Journal of biological chemistry2017
Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71citing papers in PubMed
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Who cites it
71 citing papers in PubMed, 116 citations in OpenAlex.
- SUCLG2 contributes to platinum resistance in lung adenocarcinoma through enhancing succinylation of GAC and glutamine metabolism.Apoptosis : an international journal on programmed cell death · 2026Article
- Protective role of HOXB5-orchestrated mitochondrial homeostasis and mitophagy in cardiomyocytes after ischemia-reperfusion via transcriptionally activating Sirt5.Cardiovascular drugs and therapy · 2026Article
- Article
- Unveiling the importance of SIRT5 for cardiac health and disease in an era of increasing longevity.GeroScience · 2026Review
- The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.PLoS pathogens · 2026Article
- Targeting MFF succinylation: a novel therapeutic strategy for premature ovarian insufficiency by restoring mitochondrial dynamics in granulosa cells.Journal of ovarian research · 2026Review
- Metabolism-driven emerging acylation modifications in COPD: from elucidation of fundamental mechanisms to clinical diagnosis and treatment.Frontiers in immunology · 2026Review
- The role of lysine acylation in metabolic dysregulation and inflammatory responses within the hepatic immune microenvironment of MASLD.Frontiers in immunology · 2026Review
- SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence.Communications biology · 2025Article
- The role of succinylation-mediated metabolic reprogramming in tumor progression.Molecular biology reports · 2025Review
- Succinylation regulates boar sperm linear motility via reprogramming glucose metabolism.Communications biology · 2025Article
- SIRT5: a potential target for discovering bioactive natural products.Journal of natural medicines · 2025Review
- Review
- Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome.Biomolecules · 2024Article
- Catalpol improved energy metabolism and inflammation through the SIRT5-mediated signaling pathway to ameliorate myocardial injury.Scientific reports · 2024Article
- Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism.Journal of neuroinflammation · 2024Article
- Characteristics, clinical significance, and cancer immune interactions of lipid metabolism in prostate cancer.Translational cancer research · 2024Article
- Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.iScience · 2024Article
- Succinylation modification: a potential therapeutic target in stroke.Neural regeneration research · 2024Review
- Protein succinylation, hepatic metabolism, and liver diseases.World journal of hepatology · 2024Review
11 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Yuxun ZhangFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and.
Sivakama S BharathiFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and.
Matthew J RardinBuck Institute for Research on Aging, Novato, California 94945.
Jie LuFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and.
Katherine V MaringerFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and.
Sunder Sims-LucasFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and.
Edward V ProchownikFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and.
Bradford W GibsonBuck Institute for Research on Aging, Novato, California 94945.
Eric S GoetzmanFrom the Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224 and eric.goetzman@chp.edu.
University of Pittsburgh Medical Center · USBuck Institute for Research on Aging · USChildren's Hospital of Pittsburgh · US
Funding
Regulation of Peroxisomal Metabolism by Lysine AcylationR01DK090242 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOETZMAN, ERIC S · 2011 to 2024
$5.4MControl of Metabolism and Energy-Sensing Pathways by c-MycR01CA174713 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PROCHOWNIK, EDWARD VICTOR · 2014 to 2018
$1.6MRenal Stroma Derived Endothelial Precursors are Critical for Renal DevelopmentK01DK096996 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMS-LUCAS, SUNDER · 2013 to 2017
$557kThe role of oxygen tension in regulating the differentiation of nephron progenitorsF32DK111165 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARINGER, KATHERINE · 2016 to 2016
$61kNCI NIH HHS R01 CA174713NIDDK NIH HHS F32 DK111165NIDDK NIH HHS K01 DK096996NIDDK NIH HHS R01 DK090242
Abstract
SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus.
Indexed as
Models, MolecularProtein Processing, Post-TranslationalAmino Acid SubstitutionAnimalsCardiolipinsElectron Transport Chain Complex ProteinsElectron Transport Complex IElectron Transport Complex IIHEK293 CellsHepatocytesHumansLysineMiceMice, KnockoutMitochondria, LiverMitochondrial MembranesCardiolipinsElectron Transport Chain Complex ProteinsElectron Transport Complex IElectron Transport Complex IILysineRecombinant Fusion ProteinsRecombinant ProteinsSIRT5 protein, humanSIRT5 protein, mouseSirtuinscardiolipinelectron transport system (ETS)mitochondriaprotein acylationsirtuin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.