Evidence map›Paper›PMID 28458182›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2017

The attribution of animacy and agency in frontotemporal dementia versus Alzheimer's disease.

Sylvia S Fong, Pongsatorn Paholpak, Madelaine Daianu, Mariel B Deutsch, Brandalyn C Riedel, Andrew R Carr, Elvira E Jimenez, Michelle M Mather, Paul M Thompson, Mario F Mendez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sylvia S FongDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Pongsatorn PaholpakDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Psychiatry, Khon Kaen University, Khon Khaen, Thailand.
Madelaine DaianuImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Mariel B DeutschDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Icahn School of Medicine at Mount Sinai, Neurology, New York, NY, USA.
Brandalyn C RiedelImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Andrew R CarrNeurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Elvira E JimenezDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Michelle M MatherDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Los Angeles, CA, USA; Department of Engineering, University of Southern California, Los Angeles, CA, USA; Department of Neurology, University of Southern California, Los Angeles, CA, USA; Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA; Department of Psychiatry, University of Southern California, Los Angeles, CA, USA; Department of Radiology, University of Southern California, Los Angeles, CA, USA.
Mario F MendezDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA. Electronic address: mmendez@ucla.edu.
VA Greater Los Angeles Healthcare System · USUniversity of Southern California · USIcahn School of Medicine at Mount Sinai · USUniversity of California, Los Angeles · US

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
Early-Onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksRF1AG050967 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2016 to 2016
$1.9M
Multidisciplinary Study of Social Behavior and Emotion in Frontotemporal DementiaR01AG034499 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2009 to 2013
$1.9M
NIA NIH HHS R01 AG034499NIA NIH HHS RF1 AG041915NIA NIH HHS RF1 AG050967NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

Impaired attribution of animacy (state of living or being sentient) and of agency (capability of intrinsically-driven action) may underlie social behavior disturbances in behavioral variant frontotemporal dementia (bvFTD). We presented the Heider and Simmel film of moving geometric shapes to 11 bvFTD patients, 11 Alzheimer's disease (AD) patients, and 12 healthy controls (HCs) and rated their recorded verbal responses for animacy attribution and agency attribution. All participants had skin conductance (SC) continuously recorded while viewing the film, and all dementia participants underwent magnetic resonance imaging (MRI) for regions of interest. The bvFTD patients, but not the AD patients, were impaired in animacy attribution, compared to the HCs. In contrast, both bvFTD and AD groups were impaired in agency attribution, compared to the HCs, and only the HCs had increasing SC responsiveness during viewing of the film. On MRI analysis of cortical thicknesses, animacy scores significantly correlated across groups with the right pars orbitalis and opercularis; agency scores with the left inferior and superior parietal cortices and the supramarginal gyrus; and both scores with the left cingulate isthmus involved in visuospatial context. These findings suggest that bvFTD is specifically associated with impaired animacy attribution from right inferior frontal atrophy. In contrast, both dementias may have impaired agency attribution from left parietal cortical atrophy and absent SC increases during the film, a sympathetic indicator of attribution of a social "story" to the moving shapes. These findings clarify disease-related changes in social attribution and corroborate the neuroanatomical origins of animacy and agency.

Indexed as

AdultAgedAged, 80 and overAlzheimer DiseaseAtrophyBrain MappingFemaleFrontotemporal DementiaHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsAgencyAlzheimer's diseaseAnimacyFrontotemporal dementiaHeider and SimmelSocial attribution

Identifiers

PMID28458182
PMCPMC5798612
OpenAlexW2604202421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.