Evidence map›Paper›PMID 28457908›Full record

SynthesisThe Journal of investigative dermatology2017

Quantitative Evaluation of Biologic Therapy Options for Psoriasis: A Systematic Review and Network Meta-Analysis.

Zarif K Jabbar-Lopez, Zenas Z N Yiu, Victoria Ward, Lesley S Exton, M Firouz Mohd Mustapa, Eleanor Samarasekera, A David Burden, Ruth Murphy, Caroline M Owen, Richard Parslew and 3 more

Erratum issuedOpen access · hybridAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 11 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 11 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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  12. Article
  13. Review
  14. Article
  15. A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 1 country.

Zarif K Jabbar-LopezUnit for Population-Based Dermatology Research, St John's Institute of Dermatology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK.
Zenas Z N YiuDermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Victoria WardUniversity College London Hospital, London, UK.
Lesley S ExtonBritish Association of Dermatologists, London, UK.
M Firouz Mohd MustapaBritish Association of Dermatologists, London, UK.
Eleanor SamarasekeraNational Guideline Centre, Royal College of Physicians, London, UK.
A David BurdenDepartment of Dermatology, Royal Infirmary of Edinburgh, Edinburgh, UK.
Ruth MurphySheffield University Teaching Hospitals and Sheffield Children's Hospitals, Sheffield, UK.
Caroline M OwenDepartment of Dermatology, East Lancashire Hospitals NHS Trust, Royal Blackburn Hospital, Blackburn, UK.
Richard ParslewDepartment of Dermatology, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, UK.
Vanessa VenningDepartment of Dermatology, Oxford University Hospitals Foundation Trust, Oxford, UK.
Richard B WarrenDermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Catherine H SmithSt John's Institute of Dermatology, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Electronic address: catherine.smith@kcl.ac.uk.
British Association of Dermatologists · GBManchester Academic Health Science Centre · GBEast Lancashire Hospitals NHS Trust · GBEdinburgh Royal Infirmary · GBGuy's and St Thomas' NHS Foundation Trust · GBKing's College London · GBOxford University Hospitals NHS Trust · GBRoyal College of Physicians · GBRoyal Liverpool and Broadgreen University Hospital NHS Trust · GBSheffield Children's Hospital · GBUniversity College Hospital · GB

Funding

Department of Health DRF-2015-08-089Medical Research Council MR/L011808/1
6 · The paper itself

Abstract

Multiple biologic treatments are licensed for psoriasis. The lack of head-to-head randomized controlled trials makes choosing between them difficult for patients, clinicians, and guideline developers. To establish their relative efficacy and tolerability, we searched MEDLINE, PubMed, Embase, and Cochrane for randomized controlled trials of licensed biologic treatments for skin psoriasis. We performed a network meta-analysis to identify direct and indirect evidence comparing biologics with one another, methotrexate, or placebo. We combined this with hierarchical cluster analysis to consider multiple outcomes related to efficacy and tolerability in combination for each treatment. Study quality, heterogeneity, and inconsistency were evaluated. Direct comparisons from 41 randomized controlled trials (20,561 participants) were included. All included biologics were efficacious compared with placebo or methotrexate at 3-4 months. Overall, cluster analysis showed adalimumab, secukinumab, and ustekinumab were comparable in terms of high efficacy and tolerability. Ixekizumab and infliximab were differentiated by very high efficacy but poorer tolerability. The lack of longer term controlled data limited our analysis to short-term outcomes. Trial performance may not equate to real-world performance, and so results need to be considered alongside real-world, long-term safety and effectiveness data. These data suggest that it is possible to discriminate between biologics to inform clinical practice and decision making (PROSPERO 2015:CRD42015017538).

Indexed as

Biological FactorsBiological TherapyHumansPsoriasisBiological Factors

Identifiers

PMID28457908
PMCPMC5519491
OpenAlexW2609891954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.