Evidence map›Paper›PMID 28457580›Full record

ArticleNeurobiology of aging2017

TMEM230 in Parkinson's disease.

Laura Ibanez, Umber Dube, John Budde, Kathleen Black, Alexandra Medvedeva, Albert A Davis, Joel S Perlmutter, Bruno A Benitez, Carlos Cruchaga

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. The Role of TMEM230 Gene in Parkinson's Disease.Journal of Parkinson's disease · 2018
    Review
  4. Article
  5. New Genes Causing Hereditary Parkinson's Disease or Parkinsonism.Current neurology and neuroscience reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Laura IbanezDepartment of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Umber DubeDepartment of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA; Medical Scientist Training Program, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
John BuddeDepartment of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Kathleen BlackDepartment of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Alexandra MedvedevaDepartment of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Albert A DavisDepartment of Neurology, School of Medicine, Washington University in St Louis, Saint Louis, MO, USA.
Joel S PerlmutterDepartment of Neurology, School of Medicine, Washington University in St Louis, Saint Louis, MO, USA.
Bruno A BenitezDepartment of Medicine, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
Carlos CruchagaDepartment of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University in Saint Louis, Saint Louis, MO, USA. Electronic address: ccruchaga@wustl.edu.
Washington University in St. Louis · US

Funding

INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
MECHANISMS OF DEEP BRAIN STIMULATIONR01NS041509 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2015
$6.8M
VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONSR01NS058714 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2008 to 2016
$4.4M
USING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0M
Identifying Rare Variants that Increase Risk for Alzheimer's DiseaseRF1AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2019 to 2019
$3.6M
IDENTIFYING RARE VARIANTS THAT INCREASE RISK FOR ALZHEIMER'S DISEASER01AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2013 to 2017
$2.7M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
Use of Endophenotypes in the Search for Alzheimer's Disease Risk GenesR01AG035083 · NIA · WASHINGTON UNIVERSITY · PI GOATE, ALISON M · 2010 to 2014
$2.3M
NIA NIH HHS R01 AG035083NIA NIH HHS R01 AG044546NIA NIH HHS RF1 AG044546NIA NIH HHS RF1 AG053303NINDS NIH HHS R01 NS041509NINDS NIH HHS R01 NS058714NINDS NIH HHS R01 NS075321NINDS NIH HHS RF1 NS075321
6 · The paper itself

Abstract

A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, age at onset, or cerebrospinal fluid α-synuclein levels.

Indexed as

Genome-Wide Association Studyalpha-SynucleinCohort StudiesDatasets as TopicGenetic Predisposition to DiseaseGenetic VariationHumansMembrane ProteinsMolecular ChaperonesParkinson Diseasealpha-SynucleinDNAJC13 protein, humanMembrane ProteinsMolecular ChaperonesTMEM230 protein, humanGWASParkinsonTMEM230WES

Identifiers

PMID28457580
PMCPMC5526081
OpenAlexW2596870600

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.