Evidence map›Paper›PMID 28457321›Full record

ArticleThe Journal of surgical research2017

Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor.

Tyler J Loftus, Andrew J Thomson, Kolenkode B Kannan, Ines G Alamo, Harry N Ramos, Elizabeth E Whitley, Philip A Efron, Alicia M Mohr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  7. Hypoalbuminemia: Pathogenesis and Clinical Significance.JPEN. Journal of parenteral and enteral nutrition · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tyler J LoftusDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
Andrew J ThomsonDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
Kolenkode B KannanDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
Ines G AlamoDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
Harry N RamosDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
Elizabeth E WhitleyPathogenesis, LLC, Gainesville, Florida.
Philip A EfronDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida.
Alicia M MohrDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida. Electronic address: alicia.mohr@surgery.ufl.edu.
University of Florida Health · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Chronic Stress and Anemia Recovery following Major TraumaR01GM105893 · NIGMS · UNIVERSITY OF FLORIDA · PI MOHR, ALICIA M · 2013 to 2021
$3.5M
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6M
NIA NIH HHS P30 AG028740NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM105893NIGMS NIH HHS R01 GM113945NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

backgroundVascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2) regulate vascular permeability and endothelial cell survival. We hypothesized that hemorrhagic shock (HS) and chronic stress (CS) would increase expression of lung VEGF and its receptors, potentiating pulmonary edema in lung tissue. MATERIALS AND

methodsMale Sprague-Dawley rats aged 8-9 wk were randomized: naïve control, lung contusion (LC), LC followed by HS (LCHS), and LCHS with CS in a restraint cylinder for 2 h/d (LCHS/CS). Animals were sacrificed on days 1 and 7. Expressions of lung VEGF, VEGFR-1, and VEGFR-2 were determined by polymerase chain reaction. Lung Injury Score (LIS) was graded on light microscopy by inflammatory cell counts, interstitial edema, pulmonary edema, and alveolar integrity (range: 0 = normal; 8 = severe injury).

resultsSeven days after LC, lung VEGF and VEGFR-1 were increased, and lung tissue healed (LIS: 0.8 ± 0.8). However, 7 d after LCHS and LCHS/CS, lung VEGF and VEGFR-1 expressions were decreased. VEGFR-2 was also decreased after LCHS/CS. LIS was elevated 7 d after LCHS and LCHS/CS (6.5 ± 1.0 and 8.2 ± 0.8). Increased LIS after LCHS and LCHS/CS was because of higher inflammatory cell counts, increased interstitial edema, and loss of alveolar integrity, whereas pulmonary edema was unchanged.

conclusionsElevation of lung VEGF and VEGFR-1 expressions after LC alone was associated with healing of injured lung tissue. Expressions of VEGF, VEGFR-1, and VEGFR-2 were reduced after LCHS and LCHS/CS, and injured lung tissue did not heal. Persistent lung injury after severe trauma was because of inflammation rather than pulmonary edema.

Indexed as

AnimalsBiomarkersChronic DiseaseLung InjuryMalePulmonary EdemaRandom AllocationRatsRats, Sprague-DawleyShock, HemorrhagicStress, PsychologicalVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2BiomarkersKdr protein, ratVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2InflammationLung injuryPulmonary contusionPulmonary edemaTissue repairVascular endothelial growth factor

Identifiers

PMID28457321
PMCPMC5412593
OpenAlexW2548617769

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.