Evidence map›Paper›PMID 28457318›Full record

Trial reportThe Journal of surgical research2017

Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease.

Laura M Drudi, Melinda S Schaller, Jade Hiramoto, Warren Gasper, William S Harris, Nancy K Hills, S Marlene Grenon

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of surgical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Omega-3 fatty acids for intermittent claudication.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Article
  3. Article
  4. Effect of cadmium exposure on essential omega-3 fatty acids in the edible bivalve Donax trunculus.Environmental science and pollution research international · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Laura M DrudiDepartment of Surgery, McGill University, Montreal, Quebec, Canada.
Melinda S SchallerDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Jade HiramotoDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Warren GasperDepartment of Surgery, University of California, San Francisco, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California.
William S HarrisDepartment of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota; OmegaQuant Analytics, LLC, Sioux Falls, South Dakota.
Nancy K HillsDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
S Marlene GrenonDepartment of Surgery, University of California, San Francisco, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California. Electronic address: marlene.grenon@ucsf.edu.
University of California, San Francisco · USSan Francisco VA Medical Center · USMcGill University · CAUniversity of South Dakota · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Effects of fish oil on inflammation and vascular function in claudicantsK23HL122446 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRENON, MARLENE · 2014 to 2017
$806k
NCATS NIH HHS UL1 TR000004NCRR NIH HHS KL2 RR024130NHLBI NIH HHS K23 HL122446
6 · The paper itself

Abstract

backgroundThe omega-3 index represents the red blood cell (RBC) content of two major long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid, and docosahexaenoic acid. We sought to determine factors associated with a favorable response to fish oil treatment and to characterize changes in RBC PUFAs associated with fish oil supplementation.

methodsThis study was a secondary analysis of the OMEGA-PAD I trial, a randomized, double-blinded, placebo-controlled trial investigating short-duration, high-dose n-3 PUFA oral supplementation on endothelial function and inflammation in subjects with peripheral arterial disease. Patients with mild to severe claudication received either 4.4 g of fish oil providing 2.6 g of eicosapentaenoic acid and 1.8 g of docosahexaenoic acid daily (n = 40) or placebo capsules (n = 40) for 1 mo. The RBC fatty acid content was measured by gas chromatography and expressed as a percent of total fatty acids. The change in omega-3 index was calculated as the difference between pre- and post-supplementation in the fish oil and placebo groups. Univariate analysis identified predictors of change in omega-3 index, with these variables included in our multivariable model.

resultsIn the fish oil group, there was an increase in the omega-3 index (5.1± 1.3% to 9.0± 1.8%; P < 0.0001), whereas there was no change in the control group. Factors associated with a favorable response (i.e., greater than the median change of 4.06%) included a lower body mass index and higher concentrations of low-density lipoproteins. Other demographic and/or lifestyle factors such as age, race, or smoking status were unrelated to the response. Oral n-3 PUFA supplementation also decreased the n-6 PUFA content in RBCs.

conclusionsShort-term, high-dose n-3 PUFA supplementation increases the omega-3 index to a greater extent in patients with a lower body mass index and higher total and low-density lipoprotein cholesterol levels.

Indexed as

Dietary SupplementsAdultAgedBiomarkersDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFemaleHumansLogistic ModelsMaleMiddle AgedPeripheral Arterial DiseaseTreatment OutcomeBiomarkersDocosahexaenoic AcidsEicosapentaenoic AcidFish oiln-3 polyunsaturated fatty acidsOmega-3 indexPeripheral artery disease

Identifiers

PMID28457318
PMCPMC5412597
OpenAlexW2551048623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.