ArticleAntioxidants & redox signaling2017
Redox Changes During the Cell Cycle in the Embryonic Root Meristem of Arabidopsis thaliana.
Article in Antioxidants & redox signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 93 citations in OpenAlex.
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- Redox buffering and HThe Plant journal : for cell and molecular biology · 2025Article
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.Developmental cell · 2025Article
- Reactive oxygen species: balancing agents in plants.Frontiers in plant science · 2025Review
- Stem cell quiescence and dormancy in plant meristems.Journal of experimental botany · 2024Review
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.bioRxiv : the preprint server for biology · 2024Article
- Superoxide signalling and antioxidant processing in the plant nucleus.Journal of experimental botany · 2024Review
- The ascorbate-glutathione cycle coming of age.Journal of experimental botany · 2024Review
- Seed longevity and genome damage.Bioscience reports · 2024Review
- Regulation of reactive oxygen molecules in pakchoi by histone acetylation modifications under Cd stress.PloS one · 2024Article
- Reactive Oxygen Species: A Crosslink between Plant and Human Eukaryotic Cell Systems.International journal of molecular sciences · 2023Review
- Hydrogen Cyanamide Causes Reversible G2/M Cell Cycle Arrest Accompanied by Oxidation of the Nucleus and Cytosol.Antioxidants (Basel, Switzerland) · 2023Article
- Metabolic regulation of quiescence in plants.The Plant journal : for cell and molecular biology · 2023Article
- Ascorbic acid-mediated reactive oxygen species homeostasis modulates the switch from tapetal cell division to cell differentiation in Arabidopsis.The Plant cell · 2023Article
- Integration of reactive oxygen species and nutrient signalling to shape root system architecture.Plant, cell & environment · 2023Review
- Using knowledge graphs to infer gene expression in plants.Frontiers in artificial intelligence · 2023Article
- Redox status of the plant cell determines epigenetic modifications under abiotic stress conditions and during developmental processes.Journal of advanced research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to characterize redox changes in the nuclei and cytosol occurring during the mitotic cell cycle in the embryonic roots of germinating Arabidopsis seedlings, and to determine how redox cycling was modified in mutants with a decreased capacity for ascorbate synthesis.
resultsUsing an in vivo reduction-oxidation (redox) reporter (roGFP2), we show that transient oxidation of the cytosol and the nuclei occurred at G1 in the synchronized dividing cells of the Arabidopsis root apical meristem, with reduction at G2 and mitosis. This redox cycle was absent from low ascorbate mutants in which nuclei were significantly more oxidized than controls. The cell cycle-dependent increase in nuclear size was impaired in the ascorbate-deficient mutants, which had fewer cells per unit area in the root proliferation zone. The transcript profile of the dry seeds and size of the imbibed seeds was strongly influenced by low ascorbate but germination, dormancy release and seed aging characteristics were unaffected. INNOVATION: These data demonstrate the presence of a redox cycle within the plant cell cycle and that the redox state of the nuclei is an important factor in cell cycle progression.
conclusionsControlled oxidation is a key feature of the early stages of the plant cell cycle. However, sustained mild oxidation restricts nuclear functions and impairs progression through the cell cycle leading to fewer cells in the root apical meristem. Antioxid. Redox Signal. 27, 1505-1519.
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