Evidence map›Paper›PMID 28456879›Full record

Trial reportInternational journal of biometeorology2017

Anti-inflammatory effect as a mechanism of effectiveness underlying the clinical benefits of pelotherapy in osteoarthritis patients: regulation of the altered inflammatory and stress feedback response.

E Ortega, I Gálvez, M D Hinchado, J Guerrero, L Martín-Cordero, S Torres-Piles

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in International journal of biometeorology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 8 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 8 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
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  5. Efficacy of aquatic therapy for neck pain: a systematic review.International journal of biometeorology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

E OrtegaResearch Group in Immunophysiology, Department of Physiology, Faculty of Sciences, University of Extremadura, Avda. Elvas s/n, 06071, Badajoz, Spain.
I GálvezResearch Group in Immunophysiology, Department of Physiology, Faculty of Sciences, University of Extremadura, Avda. Elvas s/n, 06071, Badajoz, Spain. igalvez@unex.es.ORCID http://orcid.org/0000-0002-4294-4507
M D HinchadoResearch Group in Immunophysiology, Department of Physiology, Faculty of Sciences, University of Extremadura, Avda. Elvas s/n, 06071, Badajoz, Spain.
J GuerreroDepartment of Nursing, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
L Martín-CorderoResearch Group in Immunophysiology, Department of Nursing, University Center of Plasencia, University of Extremadura, Plasencia, Spain.
S Torres-PilesResearch Group in Immunophysiology, Department of Medical-Surgical Therapy, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
Universidad de Extremadura · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the present investigation was to evaluate whether an anti-inflammatory effect together with an improvement of the regulation of the interaction between the inflammatory and stress responses underlies the clinical benefits of pelotherapy in osteoarthritis (OA) patients. This study evaluated the effects of a 10-day cycle of pelotherapy at the spa centre 'El Raposo' (Spain) in a group of 21 OA patients diagnosed with primary knee OA. Clinical assessments included pain intensity using a visual analog scale; pain, stiffness and physical function using the Western Ontario and McMaster Universities Arthritis Index; and health-related quality of life using the EuroQol-5D questionnaire. Serum inflammatory cytokine levels (IL-1β, TNF-α, IL-8, IL-6, IL-10 and TGF-β) were evaluated using the Bio-Plex® Luminex® system. Circulating neuroendocrine-stress biomarkers, such as cortisol and extracellular 72 kDa heat shock protein (eHsp72), were measured by ELISA. After the cycle of mud therapy, OA patients improved the knee flexion angle and OA-related pain, stiffness and physical function, and they reported a better health-related quality of life. Serum concentrations of IL-1β, TNF-α, IL-8, IL-6 and TGF-β, as well as eHsp72, were markedly decreased. Besides, systemic levels of cortisol increased significantly. These results confirm that the clinical benefits of mud therapy may well be mediated, at least in part, by its systemic anti-inflammatory effects and neuroendocrine-immune regulation in OA patients. Thus, mud therapy could be an effective alternative treatment in the management of OA.

Indexed as

Mud TherapyAgedCytokinesFemaleHSP72 Heat-Shock ProteinsHumansHydrocortisoneMaleMiddle AgedOsteoarthritis, KneePain MeasurementQuality of LifeCytokinesHSP72 Heat-Shock ProteinsHydrocortisoneBalneotherapyCortisolCytokineseHsp72OsteoarthritisPeloids

Identifiers

PMID28456879
OpenAlexW2607801064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.