ArticlePediatric surgery international2017
Can common serum biomarkers predict complicated appendicitis in children?
Article in Pediatric surgery international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Differentiating Uncomplicated From Complicated Acute Appendicitis in Paediatric Patients With C-Reactive Protein and Imaging Findings-A Retrospective Single Centre Study in 1149 Patients.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Acute Appendicitis in a Pediatric Minority Population: Uncommon Presentations of a Common Disease.Cureus · 2025Article
- Analysis of Incidence and Risk Factors of Complicated Acute Appendicitis in Children: Evidence From a Tertiary Pediatric Center.International journal of pediatrics · 2025Article
- Development and validation of a nomogram for predicting perforation in the early 24 h of acute appendicitis.SAGE open medicine · 2025Article
- External validation of predictive models for diagnosis, management and severity of pediatric appendicitis.Frontiers in pediatrics · 2025Article
- Clinical characteristics and prognosis of 69 cases of neonatal appendicitis.Pediatric investigation · 2023Article
- Evaluation of systemic immune-inflammation index efficacy in predicting complicated appendicitis in pediatric emergency department.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- Hyperfibrinogenemia and hyponatremia as predictors of perforated appendicitis in children: A retrospective cohort study.International journal of colorectal disease · 2023Article
- The value of ultrasound combined with CT in identifying early low-grade appendiceal mucinous neoplasm and appendicitis.Frontiers in oncology · 2023Article
- The Management of Pediatric Acute Appendicitis-Survey among Pediatric Surgeons in Romania.Medicina (Kaunas, Lithuania) · 2022Article
- Related Markers for the Precision Diagnosis of Complex Appendicitis in Children.Frontiers in pharmacology · 2022Review
- Role of platelet indices as a biomarker for the diagnosis of acute appendicitis and as a predictor of complicated appendicitis: A meta-analysis.Annals of medicine and surgery (2012) · 2021Review
- Serum Soluble CD40 Ligand in Predicting Simple Appendicitis and Complicated Appendicitis at Different Time Points in Children.Frontiers in pediatrics · 2021Article
- Scoring System for Differentiation of Complicated Appendicitis in Pediatric Patients: Appendicitis Scoring System in Children.Global pediatric health · 2021Article
- Inflammatory Markers and Duration of Symptoms Have a Close Connection With Diagnosis and Staging of Acute Appendicitis in Children.Frontiers in pediatrics · 2021Article
- Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study.Scientific reports · 2020Article
- Article
- A clinical prediction model for complicated appendicitis in children younger than five years of age.BMC pediatrics · 2020Article
- Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines.World journal of emergency surgery : WJES · 2020Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAs appendicitis in children can be managed differently according to the severity of the disease, we investigated whether commonly used serum biomarkers on admission could distinguish between simple and complicated appendicitis.
methodsAdmission white blood cell (WBC), neutrophil (NEU), and C-reactive protein (CRP) levels were analysed by ROC curve, and Kruskal-Wallis and contingency tests. Patients were divided according to age and histology [normal appendix (NA), simple appendicitis (SA), complicated appendicitis (CA)].
resultsOf 1197 children (NA = 186, SA = 685, CA = 326), 7% were <5 years, 55% 5-12, 38% 13-17. CA patients had higher CRP and WBC levels than NA and SA (p < 0.0001). NEU levels were lower in NA compared to SA or CA (p < 0.0001), but were similar between SA and CA (p = 0.6). CA patients had higher CRP and WBC levels than SA patients in 5-12- (p < 0.0001) and 13-17-year groups (p = 0.0075, p = 0.005), but not in <5-year group (p = 0.72, p = 0.81). We found CRP >40 mg/L in 58% CA and 37% SA (p < 0.0001), and WBC >15 × 10
conclusionsAdmission CRP and WBC levels may help the clinician predict complicated appendicitis in children older than 5 years of age. Early distinction of appendicitis severity using these tests may guide caregivers in the preoperative decision-making process.
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