Evidence map›Paper›PMID 28456546›Full record

Observational studyAmerican journal of ophthalmology2017

Causes of Diplopia in Patients With Epiretinal Membranes.

Kevin K Veverka, Sarah R Hatt, David A Leske, William L Brown, Raymond Iezzi, Jonathan M Holmes

Abstract readObservational Study
In one paragraph

Observational study in American journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Prism Success in Patients with Diplopia and Retinal Pathology.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Test-retest reliability of the revised diplopia questionnaire.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Adult-onset nonparalytic, small-angle hypertropia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2018
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

  • Commented on by
    2018
5 · Who and what money

Authors and funding

6 authors.

Kevin K VeverkaMayo Clinic School of Medicine, Rochester, Minnesota.
Sarah R HattDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
David A LeskeDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
William L BrownDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Raymond IezziDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota. Electronic address: iezzi.raymond@mayo.edu.
Jonathan M HolmesDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota. Electronic address: holmes.jonathan@mayo.edu.

Funding

Outcome Measures for Clinical Trials in Pediatric Eye Care and StrabismusR01EY024333 · NEI · MAYO CLINIC ROCHESTER · PI FAUTSCH, MICHAEL P. · 2014 to 2018
$3.3M
NEI NIH HHS R01 EY024333
6 · The paper itself

Abstract

purposeTo describe the causes of diplopia in patients with an epiretinal membrane (ERM) and presenting diplopia.

designRetrospective observational case series.

methodsWe reviewed patients diagnosed with an ERM, who had been seen by both retinal and strabismus specialists in a tertiary medical center. Data recorded: orthoptic evaluation, retinal misregistration (optotype-frame test, and synoptophore central peripheral superimposition slides at 5 and 10 degrees), and cause of any diplopia (retinal misregistration vs strabismus vs optical/refractive error). We defined central-peripheral rivalry-type diplopia as presenting symptomatic diplopia with evidence of retinal misregistration, and where other causes did not fully explain diplopia. The frequency of each cause of diplopia in patients with ERM was determined.

resultsOf 50 patients with ERM, 25 had symptomatic diplopia and 25 had no diplopia. Eleven of 25 diplopic patients (44%) had retinal misregistration as the sole cause (central-peripheral rivalry-type diplopia), 7 (28%) strabismus (1 of 7 initally appeared to have central-peripheral rivalry-type diplopia), 1 (4%) optical/refractive error (monocular diplopia), 2 (8%) mixed retinal misregistration (central-peripheral rivalry-type diplopia) and strabismus, and for 4 (16%) diplopia cause was indeterminate. Unexpectedly, 15 of 25 patients without diplopia (60%) had evidence of retinal misregistration.

conclusionsPatients with ERM and presenting diplopia may have 1 of several causes of diplopia, most commonly retinal misregistration (central-peripheral rivalry-type diplopia). Nevertheless, diplopic patients with retinal misregistration may also have treatable strabismus or optical/refractive error as the primary barrier to single vision and therefore many potential barriers to single vision should be considered.

Indexed as

Visual AcuityAgedAged, 80 and overDiplopiaEpiretinal MembraneFemaleHumansMaleMiddle AgedRetinaRetrospective StudiesTomography, Optical CoherenceVision, Binocular

Identifiers

PMID28456546
PMCPMC5699521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.