ArticleThe Journal of physiology2017
Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Danicamtiv increases cardiac mechanical efficiency.The Journal of physiology · 2025Article
- Cardiac muscle contracts more efficiently at lower contraction frequencies.Experimental physiology · 2025Article
- Resolving an inconsistency in the estimation of the energy for excitation of cardiac muscle contraction.Frontiers in physiology · 2023Article
- Cardiac efficiency and Starling's Law of the Heart.The Journal of physiology · 2022Article
- Cross-bridge thermodynamics in pulmonary arterial hypertensive right-ventricular failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function.The Journal of general physiology · 2021Article
- The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle.Journal of muscle research and cell motility · 2021Article
- An Equivocal Final Link - Quantitative Determination of the Thermodynamic Efficiency of ATP Hydrolysis - Sullies the Chain of Electric, Ionic, Mechanical and Metabolic Steps Underlying Cardiac Contraction.Frontiers in physiology · 2020Article
- Energy expenditure for isometric contractions of right and left ventricular trabeculae over a wide range of frequencies at body temperature.Scientific reports · 2019Article
- Pulmonary arterial hypertension reduces energy efficiency of right, but not left, rat ventricular trabeculae.The Journal of physiology · 2018Article
- Do right-ventricular trabeculae gain energetic advantage from having a greater velocity of shortening?The Journal of physiology · 2017Article
- Experimental and modelling evidence of shortening heat in cardiac muscle.The Journal of physiology · 2017Article
- To the heart of activation heat.The Journal of physiology · 2017Article
- Heart heat separation.The Journal of physiology · 2017Article
- Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure.Frontiers in physiology · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsThe heat of activation of cardiac muscle reflects the metabolic cost of restoring ionic homeostasis following a contraction. The accuracy of its measurement depends critically on the abolition of crossbridge cycling. We abolished crossbridge activity in isolated rat ventricular trabeculae by use of blebbistatin, an agent that selectively inhibits myosin II ATPase. We found cardiac activation heat to be muscle length independent and to account for 15-20% of total heat production at body temperature. We conclude that it can be accurately estimated at minimal muscle length. ABSTRACT: Activation heat arises from two sources during the contraction of striated muscle. It reflects the metabolic expenditure associated with Ca
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