Evidence map›Paper›PMID 28455830›Full record

Observational studyInternational journal of clinical pharmacy2017

The "iatrogenic triad": polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults.

Priscila Horta Novaes, Danielle Teles da Cruz, Alessandra Lamas Granero Lucchetti, Isabel Cristina Gonçalves Leite, Giancarlo Lucchetti

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of clinical pharmacy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Prevalence of Polypharmacy of Older People in a Large Brazilian Urban Center and its Associated Factors.International journal of environmental research and public health · 2023
    Article
  15. Article
  16. Article
  17. Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study.International journal of environmental research and public health · 2022
    Observational
  18. Article
  19. Polypharmacy in Polish Older Adult Population-A Cross-Sectional Study: Results of the PolSenior Project.International journal of environmental research and public health · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Priscila Horta NovaesSchool of Medicine, Federal University of Juiz de Fora, Av. Eugenio do Nascimento s/n - Dom Bosco, Juiz de Fora, MG, CEP 36038330, Brazil.
Danielle Teles da CruzSchool of Medicine, Federal University of Juiz de Fora, Av. Eugenio do Nascimento s/n - Dom Bosco, Juiz de Fora, MG, CEP 36038330, Brazil.
Alessandra Lamas Granero LucchettiSchool of Medicine, Federal University of Juiz de Fora, Av. Eugenio do Nascimento s/n - Dom Bosco, Juiz de Fora, MG, CEP 36038330, Brazil.
Isabel Cristina Gonçalves LeiteSchool of Medicine, Federal University of Juiz de Fora, Av. Eugenio do Nascimento s/n - Dom Bosco, Juiz de Fora, MG, CEP 36038330, Brazil.
Giancarlo LucchettiSchool of Medicine, Federal University of Juiz de Fora, Av. Eugenio do Nascimento s/n - Dom Bosco, Juiz de Fora, MG, CEP 36038330, Brazil. g.lucchetti@yahoo.com.br.
Universidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The elderly population is often in continuous use of several medications and is more subject to the "iatrogenic triad" of polypharmacy, potentially inappropriate medication use and drug-drug interactions. However, few studies have investigated these three factors concomitantly. Purpose To assess the prevalence and inter-relationship of potentially inappropriate medication (PIM) use, polypharmacy and drug-drug interactions in older adults, together with their associated factors. Setting city of Juiz de Fora, Brazil. Methods a cross-sectional, observational and door-to-door epidemiologic study in community-dwelling older adults was conducted. Main outcome measure The primary outcomes were polypharmacy, inappropriate medication use (2012 Beers and 2015 STOPP criteria) and drug-drug interactions. Associated factors were also investigated using bivariate and multivariate analyses. Results a total of 368 (92%) older adults were in continuous use of at least one drug. There was a high prevalence of polypharmacy (44.6%), drug-drug interaction (72.3%) and PIMs by Beers (42.1%) and PIMs by STOPP (46.2%). Analysis of the inter-relationship of the criteria (polypharmacy, PIMs STOPP and drug-drug interactions) revealed that 108 (29.3%) of the older adults had all three criteria concomitantly and multivariate analysis showed that frailty and having a caregiver were associated with this "iatrogenic triad". Conclusion A high prevalence of iatrogenic effects from drugs was found in the older adults assessed. One in every three elderly participants of the study had all three iatrogenic criteria concomitantly, highlighting the major public health impact of this problem. The results of this study can serve to inform new preventive and educational strategies for health professionals.

Indexed as

PolypharmacyAgedAged, 80 and overBrazilCross-Sectional StudiesDrug InteractionsFemaleHumansIatrogenic DiseaseInappropriate PrescribingIndependent LivingMalePotentially Inappropriate Medication ListRisk FactorsSurveys and QuestionnairesBrazilDrug interactionsInappropriate prescribingPolypharmacy

Identifiers

PMID28455830
OpenAlexW2608405285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.