ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017
Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Glycocalyx and Endothelial Biomarkers as Prognostic Indicators in Sepsis: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2025Pooled it
- Endocan attenuates LPS-induced alveolar type II cells injury through PI3K/Akt/mTOR pathway.Upsala journal of medical sciences · 2026Article
- Endocan as a biomarker for acute respiratory distress syndrome: A systematic review and meta-analysis.Health science reports · 2024Review
- Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions.International journal of molecular sciences · 2023Article
- Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis.iScience · 2023Article
- Assessment of plasma endocan for the prediction of mortality in COVID-19 patients undergoing veno-venous ECMO: A pilot study.Medicina intensiva · 2023Article
- Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score.Journal of clinical medicine · 2022Article
- Endothelitis profile in acute heart failure and cardiogenic shock patients: Endocan as a potential novel biomarker and putative therapeutic target.Frontiers in physiology · 2022Article
- Novel Perspectives Regarding the Pathology, Inflammation, and Biomarkers of Acute Respiratory Distress Syndrome.International journal of molecular sciences · 2020Review
- Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.Critical care medicine · 2020Observational
- Review
- The complex kinetics of blood endocan during the time course of sepsis and acute respiratory distress syndrome.Critical care (London, England) · 2019Article
- Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients.Canadian respiratory journal · 2019Article
- Endocan, sepsis, pneumonia, and acute respiratory distress syndrome.Critical care (London, England) · 2018Review
- Role of the extracellular matrix in the genesis of ventilator-induced lung injury.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Endothelial Microvesicles and Soluble Markers of Endothelial Injury in Critically Ill Newborns.Mediators of inflammation · 2018Article
- Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome.Annals of intensive care · 2017Article
- Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome.Disease markers · 2017Observational
- The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia.Pakistan journal of medical sciencesArticle
- Reactive hyperemia correlates with the presence of sepsis and glycocalyx degradation in the intensive care unit: a prospective cohort study.Revista Brasileira de terapia intensivaArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How circulating inflammatory mediators change upon sepsis progression has not been studied. We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Endocan and Ang-2 were the only parameters that were significantly increased among patients who worsened. Any increase of endocan was associated with worsening with odds ratio 16.65 (p < 0.0001). This increase was independently associated with progression into acute respiratory distress syndrome (ARDS) as shown after logistic regression analysis (odds ratio 2.91, p: 0.002). Changes of circulating cytokines do not mediate worsening of the critically ill patients. Instead endocan and Ang2 are increased and this may be interpreted as a key-playing role in the pathogenesis of ARDS and septic shock. Any increase of endocan is a surrogate of worsening of the clinical course.
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