ArticleJournal of neurology2018
Revisiting 'progressive stroke': incidence, predictors, pathophysiology, and management of unexplained early neurological deterioration following acute ischemic stroke.
Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients.BMC neurology · 2025Pooled it
- Low-Molecular-Weight Heparin Versus Aspirin in Early Management of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Impact of Prestroke Antiplatelet Therapy on the Efficacy of Intravenous Tirofiban at Preventing Early Neurological Deterioration: A Prespecified Subgroup Analysis of the TREND Trial.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Trial
- Trial
- Review
- Endovascular revascularization for progressive stroke beyond conventional time windows: safety, efficacy, and predictors of technical failure and restenosis.Neurosurgical review · 2026Article
- Effects of anemia on short-term prognosis and imaging features of patients with acute ischemic stroke: preliminary findings.BMC neurology · 2026Article
- Acute Treatment of Disabling and Nondisabling Minor Ischemic Stroke: Expert Guidance for Clinicians.Stroke · 2026Review
- Incidence, outcomes and risk factors of rebound neurological deterioration after initial improvement following intravenous thrombolysis: a retrospective cohort study.Frontiers in aging neuroscience · 2026Article
- Comparison of clinical efficacy between argatroban and tirofiban in patients with atherosclerotic cerebral infarction complicated by early neurological deterioration.Frontiers in pharmacology · 2026Article
- Safety and efficacy of endovascular treatment for progressive large vessel occlusion stroke presenting 24-72 h after onset: a propensity score-matched analysis.Frontiers in neurology · 2026Article
- Nomogram for predicting the occurrence of progressive ischemic stroke: a single-center retrospective study.European journal of medical research · 2025Article
- Association of blood pressure parameters on early neurological deterioration in patients with mild stroke and large vessel occlusion following medical management.BMC neurology · 2025Article
- Role of human urinary kallikrein in reducing progressive ischemic stroke among acute ischemic stroke patients with concurrent hypertension and diabetes: a hospital-based retrospective cohort study.Frontiers in neurology · 2025Article
- Intravenous thrombolysis prevents neurological deterioration in patients with acute pontine infarction.Frontiers in neurology · 2025Article
- Safety and efficacy of rescue endovascular treatment in ischemic stroke patients with early neurological deterioration caused by large vessel occlusion.American journal of translational research · 2025Article
- Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy.Frontiers in aging neuroscience · 2025Article
- Article
- Monitoring of Perioperative Microcirculation Dysfunction by Near-Infrared Spectroscopy for Neurological Deterioration and Prognosis of Aneurysmal Subarachnoid Hemorrhage: An Observational, Longitudinal Cohort Study.Neurology and therapy · 2024Article
- Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow.European stroke journal · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early neurological deterioration (END) following acute ischemic stroke is a serious clinical event strongly associated with poor outcome. Regarding specifically END occurring within 24 h following stroke onset, apart from straightforward causes such as symptomatic intracranial haemorrhage and malignant edema, the cause of END remains unclear in more than a half of cases. In the latter situation, patients are often referred to as 'progressive stroke', a default clinical category that does not imply underlying mechanisms, precluding informed management. In this review article, we summarize the available evidence on the incidence, predictors, and associated factors of unexplained END, and discuss its underlying pathophysiology. We particularly address the hemodynamic and thrombotic mechanisms that likely play a critical role in unexplained END, and in turn highlight potential new avenues to prevent and manage this ominous event.
Indexed as
Identifiers
28455666What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.