ArticleScientific reports2017
Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The Role of Long Intergenic Noncoding RNA in Fetal Development.International journal of molecular sciences · 2024Review
- Systematic Identification of Long Noncoding RNAs during Three Key Organogenesis Stages in Zebrafish.International journal of molecular sciences · 2024Article
- Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region.Cellular and molecular life sciences : CMLS · 2021Article
- MIC-Drop: A platform for large-scale in vivo CRISPR screens.Science (New York, N.Y.) · 2021Article
- Mutation of a major CG methylase alters genome-wide lncRNA expression in rice.G3 (Bethesda, Md.) · 2021Article
- Identification, functional prediction, and key lncRNA verification of cold stress-related lncRNAs in rats liver.Scientific reports · 2020Article
- A temporal transcriptome and methylome in human embryonic stem cell-derived cardiomyocytes identifies novel regulators of early cardiac development.Epigenetics · 2018Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as potential key regulators of heart development and related diseases, but their identities and functions remain elusive. In this study, we sought to identify and characterize the cardiac lincRNA transcriptome in the experimentally accessible zebrafish model by integrating bioinformatics analysis with experimental validation. By conducting genome-wide RNA sequencing profiling of zebrafish embryonic hearts, adult hearts, and adult muscle, we generated a high-confidence set of 813 cardiac lincRNA transcripts, 423 of which are novel. Among these lincRNAs, 564 are expressed in the embryonic heart, and 730 are expressed in the adult heart, including 2 novel lincRNAs, TCONS_00000891 and TCONS_00028686, which exhibit cardiac-enriched expression patterns in adult heart. Using a method similar to a fetal gene program, we identified 51 lincRNAs with differential expression patterns between embryonic and adult hearts, among which TCONS_00009015 responded to doxorubicin-induced cardiac stress. In summary, our genome-wide systematic identification and characterization of cardiac lincRNAs lays the foundation for future studies in this vertebrate model to elucidate crucial roles for cardiac lincRNAs during heart development and cardiac diseases.
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Registered trials
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