ArticleScientific reports2017
Genome-wide fitness analyses of the foodborne pathogen Campylobacter jejuni in in vitro and in vivo models.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Comprehensive genomic insights into lineages, virulence, and antibiotic resistance profiles of Campylobacter jejuni entailing a global One Health scenario.Gut pathogens · 2026Article
- Hi-C Metagenome Deconvolution of Double-Crested Cormorant (Microorganisms · 2026Article
- Caecal microbiome transplant inhibits transmission and intestinal colonisation ofPoultry science and management · 2026Article
- UnravelingmSystems · 2025Article
- Interplay of two small RNAs fine-tunes hierarchical flagella gene expression in Campylobacter jejuni.Nature communications · 2024Article
- Review
- Identification of Campylobacter jejuni and Campylobacter coli genes contributing to oxidative stress response using TraDIS analysis.BMC microbiology · 2024Article
- Transcriptome Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Application of TraDIS to define the core essential genome of Campylobacter jejuni and Campylobacter coli.BMC microbiology · 2023Article
- Molecular Targets inBiomolecules · 2023Review
- The Use of Interdisciplinary Approaches to Understand the Biology ofMicroorganisms · 2022Review
- Polar localization of CheO under hypoxia promotes Campylobacter jejuni chemotactic behavior within host.PLoS pathogens · 2022Article
- Development and validation of a CRISPR interference system for gene regulation in Campylobacter jejuni.BMC microbiology · 2022Article
- Transient internalization ofMicrobiology (Reading, England) · 2022Article
- Detecting Glucose Fluctuations in theACS chemical biology · 2021Article
- The Host Cellular Immune Response to Infection by Campylobacter Spp. and Its Role in Disease.Infection and immunity · 2021Review
- Genome-wide insights into population structure and host specificity of Campylobacter jejuni.Scientific reports · 2021Article
- Characterizing the immune response of chickens to Campylobacter jejuni (Strain A74C).PloS one · 2021Article
- Population Biology and Comparative Genomics of Campylobacter Species.Current topics in microbiology and immunology · 2021Review
- Small-scaled association between ambient temperature and campylobacteriosis incidence in Germany.Scientific reports · 2020Article
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Authors and funding
22 authors.
Funding
Abstract
Campylobacter is the most common cause of foodborne bacterial illness worldwide. Faecal contamination of meat, especially chicken, during processing represents a key route of transmission to humans. There is a lack of insight into the mechanisms driving C. jejuni growth and survival within hosts and the environment. Here, we report a detailed analysis of C. jejuni fitness across models reflecting stages in its life cycle. Transposon (Tn) gene-inactivation libraries were generated in three C. jejuni strains and the impact on fitness during chicken colonisation, survival in houseflies and under nutrient-rich and -poor conditions at 4 °C and infection of human gut epithelial cells was assessed by Tn-insertion site sequencing (Tn-seq). A total of 331 homologous gene clusters were essential for fitness during in vitro growth in three C. jejuni strains, revealing that a large part of its genome is dedicated to growth. We report novel C. jejuni factors essential throughout its life cycle. Importantly, we identified genes that fulfil important roles across multiple conditions. Our comprehensive screens showed which flagella elements are essential for growth and which are vital to the interaction with host organisms. Future efforts should focus on how to exploit this knowledge to effectively control infections caused by C. jejuni.
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