Evidence map›Paper›PMID 28455451›Full record

ArticlePhysiological reports2017

Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.

Homare Okamura, Fabian Emrich, Jeffrey Trojan, Peter Chiu, Alex R Dalal, Mamoru Arakawa, Tetsuya Sato, Kiril Penov, Tiffany Koyano, Albert Pedroza and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Homare OkamuraDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Fabian EmrichDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Jeffrey TrojanDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Peter ChiuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Alex R DalalDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Mamoru ArakawaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Tetsuya SatoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Kiril PenovDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Tiffany KoyanoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Albert PedrozaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Andrew J ConnollyDepartment of Pathology, Stanford University, Stanford, California.
Marlene RabinovitchDepartment of Pediatrics, Stanford University, Stanford, California.
Cristina AlviraDepartment of Pediatrics, Stanford University, Stanford, California.
Michael P FischbeinDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California mfischbe@stanford.edu.
Stanford University · US

Funding

Marfan Aortic Embryologic Origin Influences miR-29b Regulators and TargetsR01AR066629 · NIAMS · STANFORD UNIVERSITY · PI FISCHBEIN, MICHAEL PETER · 2016 to 2020
$1.5M
NIAMS NIH HHS R01 AR066629
6 · The paper itself

Abstract

Aortic root aneurysm formation and subsequent dissection and/or rupture remain the leading cause of death in patients with Marfan syndrome. Our laboratory has reported that miR-29b participates in aortic root/ascending aorta extracellular matrix remodeling during early aneurysm formation in

Indexed as

AnimalsAortic AneurysmDisease Models, AnimalDisease ProgressionEchocardiographyElastinExtracellular MatrixFemaleFetal TherapiesGenetic TherapyMaleMarfan SyndromeMatrix MetalloproteinasesMice, Inbred C57BLMice, Mutant StrainsMicroRNAsElastinMatrix MetalloproteinasesMicroRNAsMIRN29 microRNA, mouseAneurysmsaortaMarfan syndromemicroRNA

Identifiers

PMID28455451
PMCPMC5408287
OpenAlexW2608631020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.