Evidence map›Paper›PMID 28455444›Full record

ArticleThe Journal of biological chemistry2017

Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection.

Jacob M Serfass, Yoshinori Takahashi, Zhixiang Zhou, Yuka Imamura Kawasawa, Ying Liu, Nikolaos Tsotakos, Megan M Young, Zhenyuan Tang, Linlin Yang, Jennifer M Atkinson and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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  19. Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids.Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Jacob M SerfassFrom the Department of Pharmacology.ORCID 0000-0002-5726-5718
Yoshinori Takahashithe Department of Pediatrics, ytakahashi@pennstatehealth.psu.edu.
Zhixiang Zhouthe Department of Pediatrics.
Yuka Imamura KawasawaFrom the Department of Pharmacology.
Ying LiuFrom the Department of Pharmacology.
Nikolaos Tsotakosthe Department of Pediatrics.
Megan M Youngthe Department of Pediatrics.
Zhenyuan Tangthe Department of Pediatrics.
Linlin Yangthe Department of Pediatrics.
Jennifer M Atkinsonthe Department of Pediatrics.
Zissis C Chroneosthe Department of Pediatrics.
Hong-Gang WangFrom the Department of Pharmacology, hwang3@pennstatehealth.psu.edu.
Baystate Health · USBeijing University of Technology · CNeHealth Africa · USLaboratory for Personalized Molecular Medicine · USPennsylvania State University · US

Funding

POSTTRANSLATIONAL MODIFICATIONS OF BADR01CA082197 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, HONG-GANG · 1999 to 2015
$3.3M
Regulation of Autophagy and Tumorigenesis by Bif-1R01CA129682 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WANG, HONG-GANG · 2009 to 2013
$1.6M
Regulation of the lung antiviral inflammatory responseR56HL128746 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHRONEOS, ZISSIS C · 2015 to 2015
$387k
NCI NIH HHS R01 CA082197NCI NIH HHS R01 CA129682NHLBI NIH HHS R56 HL128746
6 · The paper itself

Abstract

Endocytosis, and the subsequent trafficking of endosomes, requires dynamic physical alterations in membrane shape that are mediated in part by endophilin proteins. The endophilin B family of proteins contains an N-terminal Bin/amphiphysin/Rvs (N-BAR) domain that induces membrane curvature to regulate intracellular membrane dynamics. Whereas endophilin B1 (SH3GLB1/Bif-1) is known to be involved in a number of cellular processes, including apoptosis, autophagy, and endocytosis, the cellular function of endophilin B2 (SH3GLB2) is not well understood. In this study, we used genetic approaches that revealed that endophilin B2 is not required for embryonic development

Indexed as

AutophagySignal TransductionAdaptor Proteins, Signal TransducingAnimalsApoptosisCarrier ProteinsCell LineCells, CulturedEndocytosisEndosomesEpidermal Growth FactorErbB ReceptorsHumansInfluenza A virusMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal TransducingCarrier ProteinsEpidermal Growth FactorErbB ReceptorsRecombinant Fusion ProteinsSH3GLB2 protein, humanSh3glb2 protein, mouseautophagyEGFR degradationendocytosisEndophilin B2endosome maturationinfluenzaintracellular traffickingSH3GLB2virus entry

Identifiers

PMID28455444
PMCPMC5473216
OpenAlexW2609784270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.