ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity.Cell reports · 2026Article
- Memory Phenotype Tfh Cells Develop Without Overt Infection and Support Germinal Center Formation and B Cell Responses to Viral Infection.European journal of immunology · 2025Article
- C6 Ceramide Inhibits Canine Mammary Cancer Growth and Metastasis by Targeting EGR3 through JAK1/STAT3 Signaling.Animals : an open access journal from MDPI · 2024Article
- Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.Cancer immunology, immunotherapy : CII · 2023Article
- Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria.Molecular systems biology · 2022Article
- EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.Frontiers in immunology · 2022Article
- Host-virus interaction and viral evasion.Cell biology international · 2021Review
- Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation.Nature communications · 2021Article
- The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells.Molecular and cellular endocrinology · 2021Article
- Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy.Cell research · 2020Article
- Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1Life science alliance · 2020Article
- EGR2 is elevated and positively regulates inflammatory IFNγ production in lupus CD4BMC immunology · 2020Article
- Suppression of CaEMBO reports · 2020Article
- BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation.Frontiers in immunology · 2019Article
- GWAS Follow-up Study Discovers a Novel Genetic Signal on 10q21.2 for Atopic Dermatitis in Chinese Han Population.Frontiers in genetics · 2019Article
- EGR-mediated control of STIM expression and function.Cell calcium · 2019Review
- Effects of various radiation doses on induced T-helper cell differentiation and related cytokine secretion.Journal of radiation research · 2018Article
- Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.Immunity, inflammation and disease · 2018Article
- Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8The Journal of experimental medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet function in CD4 and CD8 effector T cells. Egr2 and 3 were essential to suppress Th1 differentiation in Th2 and Th17 conditions in vitro and also to control IFN-γ-producing CD4 and CD8 T cells in response to virus infection. Together with Egr2 and 3, T-bet is induced in naive T cells by Ag stimulation, but Egr2 and 3 expression was inhibited by Th1-inducing cytokines. We found that Egr2 and 3 physically interact with the T-box domain of T-bet, blocking T-bet DNA binding and inhibiting T-bet-mediated production of IFN-γ. Thus, Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.