Evidence map›Paper›PMID 28455373›Full record

ArticleDevelopment (Cambridge, England)2017

ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network.

Kazunari Matsuda, Tomoyuki Mikami, Shinya Oki, Hideaki Iida, Munazah Andrabi, Jeremy M Boss, Katsushi Yamaguchi, Shuji Shigenobu, Hisato Kondoh

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

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  7. BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  13. Enhancer Activation by Transcription Factors and Underlying Mechanisms.Results and problems in cell differentiation · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kazunari MatsudaGraduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan.
Tomoyuki MikamiGraduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-4335-4418
Shinya OkiDepartment of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Hideaki IidaFaculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan.
Munazah AndrabiGraduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan.
Jeremy M BossDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-2432-1840
Katsushi YamaguchiFunctional Genomics Facility, National Institute for Basic Biology, Okazaki, Aichi 444-8585, Japan.
Shuji ShigenobuFunctional Genomics Facility, National Institute for Basic Biology, Okazaki, Aichi 444-8585, Japan.ORCID 0000-0003-4640-2323
Hisato KondohGraduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan kondohh@cc.kyoto-su.ac.jp.ORCID 0000-0002-3609-7014
The University of Osaka · JPKyoto Sangyo University · JPNational Institute for Basic Biology · JPEmory University · USKyushu University · JP

Funding

Epigenetic Regulation of Plasma Cells DifferentiationR01AI123733 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI123733
6 · The paper itself

Abstract

To obtain insight into the transcription factor (TF)-dependent regulation of epiblast stem cells (EpiSCs), we performed ChIP-seq analysis of the genomic binding regions of five major TFs. Analysis of

Indexed as

Chromatin ImmunoprecipitationGene Expression Regulation, DevelopmentalGene Regulatory NetworksSequence Analysis, RNAAnimalsBinding SitesBiotinylationGenomeGerm LayersHumansMiceMouse Embryonic Stem CellsOctamer Transcription Factor-3Otx Transcription FactorsProtein BindingSOXB1 Transcription FactorsOctamer Transcription Factor-3Otx2 protein, mouseOtx Transcription FactorsPou5f1 protein, mouseSOXB1 Transcription FactorsTranscription FactorsZic2 protein, mouseEpiSCESCMouseOTX2POU3F1ZIC2

Identifiers

PMID28455373
PMCPMC5482983
OpenAlexW2610019744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.