Evidence map›Paper›PMID 28455362›Full record

SynthesisBritish journal of sports medicine2017

A systematic review of potential long-term effects of sport-related concussion.

Geoff Manley, Andrew J Gardner, Kathryn J Schneider, Kevin M Guskiewicz, Julian Bailes, Robert C Cantu, Rudolph J Castellani, Michael Turner, Barry D Jordan, Christopher Randolph and 5 more

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07025317 (Developing an Evidence-based Approach to Diagnose and Treat Adults With a History of Concussion), which is not on this map. Cited by 250 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 12 pooled it
38.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07025317 narecruitingnot on this mapstarted 2024, after this paper: background citation

Developing an Evidence-based Approach to Diagnose and Treat Adults With a History of Concussion

TypeinterventionalSponsorUniversité de MontréalRan2024 to 2027Enrolled200ConditionsBrain Injury Traumatic MildArmsPerceptual-cognitive
3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 12 syntheses or guidelines pooled it, 654 citations in OpenAlex.

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  4. A systematic review on the risk of neurodegenerative diseases and neurocognitive disorders in professional and varsity athletes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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  13. Trial
  14. Shared Decision-Making Within Families About Returning to Sport After Recovery From Concussion: Exploring Parent and Adolescent Perspectives.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
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190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 4 countries.

Geoff ManleyDepartment of Neurological Surgery, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.ORCID http://orcid.org/0000-0002-0926-3128
Andrew J GardnerCentre for Stroke and Brain Injury, School of Medicine and Public Health, University of Newcastle; Hunter New England Local Health District Sports Concussion Program, John Hunter Hospital, Newcastle, Australia.
Kathryn J SchneiderSport Injury Prevention Research Centre, Faculty of Kinesiology; Alberta Children's Hospital Research Institute for Child & Maternal Health, Cumming School of Medicine; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Kevin M GuskiewiczDepartment of Exercise and Sport Science, Matthew Gfeller Sport-Related TBI Research Center, University of North Carolina, Chapel Hill, USA.
Julian BailesDepartment of Neurosurgery, NorthShore University Health System, Co-Director, NorthShore Neurological Institute; University of Chicago Pritzker School of Medicine, Evanston, USA.
Robert C CantuDepartment of Neurosurgery, Emerson Hospital, Concord, MA, and Center for the Study of Traumatic Encephalopathy, Boston University Medical Center, Boston, USA.
Rudolph J CastellaniCenter for Neuropathology, Western Michigan University, and Homer Stryker MD School of Medicine, Kalamazoo, USA.
Michael TurnerThe International Concussion and Head Injury Research Foundation, Marylebone, UK.
Barry D JordanBurke Rehabilitation Hospital, White Plains, USA.
Christopher RandolphLoyola University Medical Center, Maywood, USA.
Jiří DvořákDepartment of Nerology, University of Zurich, Schulthess Clinic, Swiss Concussion Center, Zurich, Switzerland.
K Alix HaydenLibraries and Cultural Resources, University of Calgary, Calgary, Canada.
Charles H TatorCanadian Concussion Centre, Toronto Western Hospital, University of Toronto, Krembil Neuroscience Centre, Toronto, Canada.
Paul McCroryThe Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre - Austin Campus, Heidelberg, Australia.
Grant L IversonDepartment of Physical Medicine and Rehabilitation, Harvard Medical School; Spaulding Rehabilitation Hospital; MassGeneral Hospital for Children Sports Concussion Program; & Home Base, a Red Sox Foundation and Massachusetts General Hospital Program, Boston, USA.
University of Calgary · CABoston University · USBurke Rehabilitation Hospital · USFlorey Institute of Neuroscience and Mental Health · AUHarvard University · USJohn Hunter Hospital · AULoyola University Medical Center · USNorthShore University HealthSystem · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USUniversity of Toronto · CAUniversity of Zurich · CHWestern Michigan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSystematic review of possible long-term effects of sports-related concussion in retired athletes. DATA SOURCES: Ten electronic databases. STUDY SELECTION: Original research; incidence, risk factors or causation related to long-term mental health or neurological problems; individuals who have suffered a concussion; retired athletes as the subjects and possible long-term sequelae defined as DATA EXTRACTION: Study population, exposure/outcome measures, clinical data, neurological examination findings, cognitive assessment, neuroimaging findings and neuropathology results. Risk of bias and level of evidence were evaluated by two authors.

resultsFollowing review of 3819 studies, 47 met inclusion criteria. Some former athletes have depression and cognitive deficits later in life, and there is an association between these deficits and multiple prior concussions. Former athletes are not at increased risk for death by suicide (two studies). Former high school American football players do not appear to be at increased risk for later life neurodegenerative diseases (two studies). Some retired professional American football players may be at increased risk for diminishment in cognitive functioning or mild cognitive impairment (several studies), and neurodegenerative diseases (one study). Neuroimaging studies show modest evidence of macrostructural, microstructural, functional and neurochemical changes in some athletes.

conclusionMultiple concussions appear to be a risk factor for cognitive impairment and mental health problems in some individuals. More research is needed to better understand the prevalence of chronic traumatic encephalopathy and other neurological conditions and diseases, and the extent to which they are related to concussions and/or repetitive neurotrauma sustained in sports.

Indexed as

AthletesAthletic InjuriesBrainBrain ConcussionCognition DisordersDepressionFootballHumansIncidenceNeuroimagingPost-Concussion SyndromeRisk Factors

Identifiers

PMID28455362
PMCPMC5466926
OpenAlexW2608826008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.