Evidence map›Paper›PMID 28455330›Full record

ArticleApplied and environmental microbiology2017

Regulation of Botulinum Neurotoxin Synthesis and Toxin Complex Formation by Arginine and Glucose in Clostridium botulinum ATCC 3502.

Chase M Fredrick, Guangyun Lin, Eric A Johnson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chase M FredrickDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Guangyun LinDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Eric A JohnsonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA eric.johnson@wisc.edu.
University of Wisconsin–Madison · US

Funding

Characterization of Botulinum Neurotoxin A SubtypesR01AI095274 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, ERIC A. · 2012 to 2016
$2.0M
NIAID NIH HHS R01 AI095274
6 · The paper itself

Abstract

Botulinum neurotoxin (BoNT), produced by neurotoxigenic clostridia, is the most potent biological toxin known and the causative agent of the paralytic disease botulism. The nutritional, environmental, and genetic regulation of BoNT synthesis, activation, stability, and toxin complex (TC) formation is not well studied. Previous studies indicated that growth and BoNT formation were affected by arginine and glucose in

Indexed as

Gene Expression Regulation, BacterialArginineBacterial ProteinsBotulinum ToxinsBotulismClostridium botulinumGlucoseHumansNeurotoxinsArginineBacterial ProteinsBotulinum ToxinsGlucoseNeurotoxinsargininebotulinum neurotoxin A1 (BoNT/A1)botulinum toxin complex (TC)Clostridium botulinum ATCC 3502glucosenutritional regulationspore formation

Identifiers

PMID28455330
PMCPMC5479000
OpenAlexW2608582473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.