Evidence map›Paper›PMID 28455104›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2017

A comparison of tuberculosis diagnostic systems in a retrospective cohort of HIV-infected children in Rio de Janeiro, Brazil.

Solange Gonçalves David, Kathryn L Lovero, Maria de Fátima B Pombo March, Thalita G Abreu, Antonio Ruffino Netto, Afranio L Kritski, Clemax C Sant'Anna, Rede-TB Study Group

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. International collaboration among medical societies is an effective way to boost Latin American production of articles on tuberculosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2019
    Article
  8. Eliminating tuberculosis in Latin America: making it the point.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2018
    Article
  9. Epidemiological aspects, clinical manifestations, and prevention of pediatric tuberculosis from the perspective of the End TB Strategy.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Solange Gonçalves DavidHospital Municipal Jesus, Rio de Janeiro, Brazil; Clinical Medicine Program, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Kathryn L LoveroDivision of Infectious Diseases and Vaccinology, and Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA. Electronic address: katelovero@berkeley.edu.
Maria de Fátima B Pombo MarchDepartment of Pediatrics, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Thalita G AbreuDepartment of Pediatrics, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Antonio Ruffino NettoRibeirão Preto School of Medicine, Federal University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Afranio L KritskiAcademic Tuberculosis Program, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Clemax C Sant'AnnaDepartment of Pediatrics, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rede-TB Study Group

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
FIC NIH HHS D43 TW010540FIC NIH HHS R25 TW009338
6 · The paper itself

Abstract

objectivesThe diagnosis of pediatric tuberculosis (TB) presents many challenges, and is further complicated in HIV-infected patients. While many diagnostic systems have been proposed, there is no pediatric TB diagnosis gold standard. The outcomes of four TB diagnostic systems in HIV-infected children were compared in this study.

methodsA retrospective cohort study was conducted at a TB/HIV reference hospital in Rio de Janeiro. HIV-infected pediatric patients evaluated for TB from 1998 to 2010 were reassessed using four diagnostic systems: Kenneth Jones, 1969; Tidjani, 1986; Ben Marais, 2006; Brazilian Ministry of Health, 2010. Results were compared to standardized diagnoses made by an expert panel of physicians.

resultsOf the 121 patients in the study cohort, the expert panel diagnosed 64 as TB and 57 as not TB cases. The Tidjani system showed the highest diagnostic accuracy, with and without the inclusion of microbiological data. The Tidjani and Kenneth Jones systems produced fewer false-positives, and the Ben Marais and Ministry of Health fewer false-negatives. Across systems, there was little agreement between TB diagnoses.

conclusionsIn HIV-infected pediatric patients, the Ben Marais and Ministry of Health systems are useful for TB diagnostic screening, whereas the Tidjani and Kenneth Jones systems are best used in a reference center setting.

Indexed as

AdolescentBrazilChildChild, PreschoolCohort StudiesDiagnostic Tests, RoutineFemaleHIV InfectionsHumansInfantMalePredictive Value of TestsRetrospective StudiesSensitivity and SpecificityTuberculosis, PulmonaryPediatric TBTB–HIV co-infectionTB scoring systems

Identifiers

PMID28455104
PMCPMC7978502

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.