Trial reportTrials2017
Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial.
Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients
Re-Evaluation of the Effects of High PEEP During General Anesthesia For Surgery - An Individual Patient Data Meta-Analysis of PROVHILO, iPROVE and PROBESE
Response of Respiratory and Hemodynamic Parameters to Positive End-Expiratory Pressure Titration for Mechanically Ventilated Obese Patients: A Randomized Clinical Trial
Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of various hypoxic preconditioning strategies on arterial oxygenation in patients undergoing one-lung ventilation during thoracoscopic surgery: a randomized clinical trial.BMC pulmonary medicine · 2026Trial
- Effects of ventilatory strategy on arterial oxygenation and respiratory mechanics in overweight and obese patients undergoing posterior spine surgery.Scientific reports · 2019Trial
- Trial
- Does Lung Compliance Optimization Through PEEP Manipulations Reduce the Incidence of Postoperative Hypoxemia in Laparoscopic Bariatric Surgery? A Randomized Trial.Obesity surgery · 2019Trial
- Effect of intraoperative high positive end-expiratory pressure with recruitment manoeuvresBJA open · 2026Article
- EIT-guided individualized PEEP titration versus conventional lung-protective ventilation to prevent pulmonary complications in laparoscopic bariatric surgery: a study protocol for a randomized controlled trial.BMC anesthesiology · 2026Article
- Application of risk prediction model to evaluate the effect of mechanical ventilation on postoperative pulmonary complications in thoracic surgery.European journal of medical research · 2025Article
- Anesthesiologic Management of Adult and Pediatric Patients with Obstructive Sleep Apnea.Healthcare (Basel, Switzerland) · 2025Review
- The Impact of Alveolar Recruitment Strategies on Perioperative Outcomes in Obese Patients Undergoing Major Gynecologic Cancer Surgeries: A Prospective Randomized Controlled Trial.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Atelectasis in obese patients undergoing laparoscopic bariatric surgery are not increased upon discharge from Post Anesthesia Care Unit.Frontiers in medicine · 2023Article
- Article
- Modified Frailty Index Independently Predicts Postoperative Pulmonary Infection in Elderly Patients Undergoing Radical Gastrectomy for Gastric Cancer.Cancer management and research · 2021Article
- Article
- Article
- Ventilation in patients with intra-abdominal hypertension: what every critical care physician needs to know.Annals of intensive care · 2019Review
- Article
- The impact of obesity on pulmonary deterioration in patients undergoing robotic-assisted laparoscopic prostatectomy.Journal of clinical monitoring and computing · 2019Article
- Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
35 authors at 19 institutions in 15 countries.
Funding
Abstract
backgroundPostoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. METHODS/
designThe PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multicenter, two-arm, international randomized controlled trial. In total, 2013 obese patients with body mass index ≥35 kg/m DISCUSSION: To our knowledge, the PROBESE trial is the first multicenter, international randomized controlled trial to compare the effects of two different levels of intraoperative PEEP during protective low tidal volume ventilation on PPCs in obese patients. The results of the PROBESE trial will support anesthesiologists in their decision to choose a certain PEEP level during general anesthesia for surgery in obese patients in an attempt to prevent PPCs.
trial registrationClinicalTrials.gov identifier: NCT02148692. Registered on 23 May 2014; last updated 7 June 2016.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.