ArticleBMC nephrology2017
Diagnosis and outcomes of acute kidney injury using surrogate and imputation methods for missing preadmission creatinine values.
Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults with shock: a NUTRIREA-3 post hoc analysis.Intensive care medicine · 2026Trial
- ICU-acquired acute kidney injury in critically ill adults: a retrospective cohort study of risk factors and KDIGO stage dynamics in a Brazilian ICU.Renal failure · 2026Article
- Concordance Analysis Between KDIGO Definition of Acute Kidney Injury and Its Coding in Clinical Practice.Kidney medicine · 2026Article
- Interpretable multi-task prediction in rhabdomyolysis: promise and caveats.EClinicalMedicine · 2026Article
- Authors' reply to: Interpretable multi-task prediction in rhabdomyolysis: promise and caveats.EClinicalMedicine · 2026Article
- Automated CT segmentation of kidneys successfully quantifies changes in total kidney volume in ICU patients, a retrospective cohort study.BMC nephrology · 2026Article
- Reference Change Value Based AKI Criteria in Critically Ill Children.Kidney international reports · 2026Article
- Response to the Letter to the Editor Entitled "The Challenges of AKI Determination in Children".Kidney international reports · 2026Article
- Discrepancies between declared and real practices of continuous renal replacement therapy for septic acute kidney injury in French intensive care units.Annals of intensive care · 2026Article
- Acute Kidney Injury Diagnostic Accuracy and Implications of Different Baseline Creatinine Equations.Kidney international reports · 2025Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.Journal of intensive care · 2025Article
- The risk of sodium overcorrections in severe hyponatremia and the utility of desmopressin: a large retrospective study.Clinical kidney journal · 2025Article
- Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury.Journal of inflammation research · 2025Article
- Kidney Blood Flow and Renin-Angiotensin-Aldosterone System Measurements Associated With Kidney and Cardiovascular Dysfunction in Pediatric Shock.Critical care explorations · 2024Observational
- The relationship between the age of onset of hypertension and chronic kidney disease: a cross-sectional study of the American population.Frontiers in cardiovascular medicine · 2024Article
- Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study.Intensive care medicine · 2023Observational
- Article
- Estimating baseline creatinine values to define acute kidney injury in critically ill pediatric patients.Kidney research and clinical practice · 2022Article
- Real-world Health Data and Precision for the Diagnosis of Acute Kidney Injury, Acute-on-Chronic Kidney Disease, and Chronic Kidney Disease: Observational Study.JMIR medical informatics · 2022Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).Journal of intensive care · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMissing preadmission serum creatinine (SCr) values are a common obstacle to assess acute kidney injury (AKI) diagnosis and outcomes. The Kidney Disease Improving Global Outcomes (KDIGO) guidelines suggest using a SCr computed from the Modification of Diet in Renal Disease (MDRD) with an estimated glomerular filtration rate of 75 ml/min/1.73 m
methodsWe compared the use of 1) first SCr at hospital admission 2) minimal SCr over 2 weeks after intensive care unit admission 3) MDRD computed SCr and 4) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) computed SCr to assess AKI diagnosis and outcomes. We then performed multilinear regression models to predict preadmission SCr and imputation strategies to assess AKI diagnosis.
resultsOur one-year retrospective cohort study included 1001 critically ill adults; 498 of them had preadmission SCr values. In these patients, AKI incidence was 25.1% using preadmission SCr. First SCr had the best agreement for AKI diagnosis (22.5%; kappa = 0.90) and staging (kappa = 0.81). MDRD, CKD-EPI and minimal SCr overestimated AKI diagnosis (26.7%, 27.1% and 43.2%;kappa = 0.86, 0.86 and 0.60, respectively). However, MDRD and CKD-EPI computed SCr had a better sensitivity than first SCr for AKI (93% and 94% vs. 87%). Eighty-eight percent of patients experienced renal recovery at least 3 months after hospital discharge. All methods except the first SCr significantly underestimated the percentage of renal recovery. In a multivariate model, age, male gender, hypertension, heart failure, undergoing surgery and log first SCr best predicted preadmission SCr (adjusted R
conclusionIn our cohort, first SCr performed better for AKI diagnosis and staging, as well as for renal recovery after hospital discharge than MDRD, CKD-EPI or minimal SCr. However, MDRD SCr and CKD-EPI SCr improved AKI diagnosis sensitivity. Imputation methods minimally increased agreement for AKI diagnosis.
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