Evidence map›Paper›PMID 28454328›Full record

ArticleOncology letters2017

Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze-dried bone marrow stem cell paracrine factors.

Ann Kakabadze, Konstantine Mardaleishvili, George Loladze, Lia Karalashvili, Gocha Chutkerashvili, David Chakhunashvili, Zurab Kakabadze

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. The effect of applying amniotic membrane on post-tonsillectomy pain and bleeding.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ann KakabadzeDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, Georgia.
Konstantine MardaleishviliDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, Georgia.
George LoladzeDepartment of Surgery, Cancer Research Center, 0177 Tbilisi, Georgia.
Lia KaralashviliDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, Georgia.
Gocha ChutkerashviliDepartment of Molecular and Translational Medicine, Institute of Medical Research, Ilia State University, 0177 Tbilisi, Georgia.
David ChakhunashviliDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, Georgia.
Zurab KakabadzeDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, Georgia.
Tbilisi State Medical University · GEIlia State University · GECancer Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gold standard following segmental mandibulectomy is vascularized autologous bone graft in the form of the fibula flap. However, in bone reconstruction the use of autogenous bone does not always guarantee a successful outcome. The aim of the present investigation was to develop a novel biologically active bone (BAB) graft, and to use it for the reconstruction of large size defects of the mandible bone following tumor resection. In the first part of the present study, biologically active bone graft was developed by using human freeze-dried bone marrow stem cells (BMSCs) paracrine factors and three-dimensional bone scaffold derived from cancellous bovine bone following decellularization. In the second part of the research, one male and three female patients with primary tumors of the mandible underwent hemimandibulectomy. The mandibular bone defects following tumor resection were reconstructed with autogenous rib grafts in three patients and BAB graft was used in one patient. The graft-host interfaces were covered with decellularized human amnion/chorion membrane graft. All patients were followed-up every five months following the reconstruction of the mandible, with no complications observed. Preliminary clinical investigations demonstrated that a BAB graft containing freeze-dried BMSC paracrine factors may be used for the reconstruction of large mandibular bone defects following tumor resection.

Indexed as

decellularized human amniotic membranefreeze-dried bone marrow stem cell paracrine factorshemimandibulectomyreconstruction of mandibular bone defectsthree-dimensional bone scaffold

Identifiers

PMID28454328
PMCPMC5403483
OpenAlexW2581734255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.